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NF-kappaB and the innate immune response.
Hatada EN, Krappmann D, Scheidereit C. Hatada EN, et al. Among authors: scheidereit c. Curr Opin Immunol. 2000 Feb;12(1):52-8. doi: 10.1016/s0952-7915(99)00050-3. Curr Opin Immunol. 2000. PMID: 10679399 Review.
Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B.
Wulczyn FG, Naumann M, Scheidereit C. Wulczyn FG, et al. Among authors: scheidereit c. Nature. 1992 Aug 13;358(6387):597-9. doi: 10.1038/358597a0. Nature. 1992. PMID: 1501714
The inhibitors I kappa B-alpha and -beta and pp40 recognize either p65 or the c-rel protein. We show here that the proto-oncogene bcl-3, believed to be involved in certain human B-cell leukaemias, encodes a protein that functions as an I kappa B-like molecule for native NF …
The inhibitors I kappa B-alpha and -beta and pp40 recognize either p65 or the c-rel protein. We show here that the proto-oncogene bcl …
The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding.
Hatada EN, Nieters A, Wulczyn FG, Naumann M, Meyer R, Nucifora G, McKeithan TW, Scheidereit C. Hatada EN, et al. Among authors: scheidereit c. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2489-93. doi: 10.1073/pnas.89.6.2489. Proc Natl Acad Sci U S A. 1992. PMID: 1532257 Free PMC article.
To date, no function has been described for the C-terminal portion. We show here that the C-terminal half of p105, when expressed as a separate molecule, binds to p50 and can rapidly disrupt protein-DNA complexes of p50 or native NF-kappa B. ...
To date, no function has been described for the C-terminal portion. We show here that the C-terminal half of p105, when expres …
Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.
Naumann M, Scheidereit C. Naumann M, et al. Among authors: scheidereit c. EMBO J. 1994 Oct 3;13(19):4597-607. EMBO J. 1994. PMID: 7925300 Free PMC article.
In HeLa cells as well as in B cells, TNF-alpha rapidly induced nuclear translocation primarily of p50-p65, but not of c-rel. ...Surprisingly, even p65, but not c-rel, was phosphorylated after induction in vivo, suggesting that TNF-alpha selectively activates only sp …
In HeLa cells as well as in B cells, TNF-alpha rapidly induced nuclear translocation primarily of p50-p65, but not of c-rel. ...Surpr …
Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3.
Hatada EN, Naumann M, Scheidereit C. Hatada EN, et al. Among authors: scheidereit c. EMBO J. 1993 Jul;12(7):2781-8. EMBO J. 1993. PMID: 8334994 Free PMC article.
The vertebrate NF-kappa B/c-rel inhibitors MAD-3/I kappa B alpha, I kappa B gamma/pdI and bcl-3 all share a conserved ankyrin repeat domain (ARD) consisting of six complete repeats, a short acidic motif and/or an incomplete seventh repeat. ...
The vertebrate NF-kappa B/c-rel inhibitors MAD-3/I kappa B alpha, I kappa B gamma/pdI and bcl-3 all share a conserved ankyrin repeat …
The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B.
Naumann M, Wulczyn FG, Scheidereit C. Naumann M, et al. Among authors: scheidereit c. EMBO J. 1993 Jan;12(1):213-22. EMBO J. 1993. PMID: 8428580 Free PMC article.
Moreover, the p105 protein inhibits DNA binding of dimeric NF-kappa B subunits in a similar, but not identical, manner to its isolated C-terminal domain, which contains an ankyrin-like repeat domain (ARD). ...
Moreover, the p105 protein inhibits DNA binding of dimeric NF-kappa B subunits in a similar, but not identical, manner to its isolated C
High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells.
Bargou RC, Leng C, Krappmann D, Emmerich F, Mapara MY, Bommert K, Royer HD, Scheidereit C, Dörken B. Bargou RC, et al. Among authors: scheidereit c. Blood. 1996 May 15;87(10):4340-7. Blood. 1996. PMID: 8639794
Unlike the constitutive NF-kappa B activity known for B cells, which mainly consists of the p50 and c-Rel or RelB subunits, we demonstrate by antibody supershifting experiments that H cells contain constitutive nuclear p50 and p65, the dimeric NF-kappa B normally observed …
Unlike the constitutive NF-kappa B activity known for B cells, which mainly consists of the p50 and c-Rel or RelB subunits, we demons …
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