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An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons.
Brandon EF, Raap CD, Meijerman I, Beijnen JH, Schellens JH. Brandon EF, et al. Among authors: schellens jh. Toxicol Appl Pharmacol. 2003 Jun 15;189(3):233-46. doi: 10.1016/s0041-008x(03)00128-5. Toxicol Appl Pharmacol. 2003. PMID: 12791308 Review.
Bayesian pharmacokinetics of lithium after an acute self-intoxication and subsequent haemodialysis: a case report.
Kerbusch T, Mathôt RA, Otten HM, Meesters EW, van Kan HJ, Schellens JH, Beijnen JH. Kerbusch T, et al. Among authors: schellens jh. Pharmacol Toxicol. 2002 May;90(5):243-5. doi: 10.1034/j.1600-0773.2002.900503.x. Pharmacol Toxicol. 2002. PMID: 12076304
Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue.
Sparidans RW, Silvertand L, Dost F, Rothbarth J, Mulder GJ, Schellens JH, Beijnen JH. Sparidans RW, et al. Among authors: schellens jh. Biomed Chromatogr. 2003 Oct;17(7):458-64. doi: 10.1002/bmc.273. Biomed Chromatogr. 2003. PMID: 14598330
In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug.
Brandon EF, Sparidans RW, Meijerman I, Manzanares I, Beijnen JH, Schellens JH. Brandon EF, et al. Among authors: schellens jh. Invest New Drugs. 2004 Aug;22(3):241-51. doi: 10.1023/B:DRUG.0000026250.34645.7f. Invest New Drugs. 2004. PMID: 15122071
Structure elucidation of aplidine metabolites formed in vitro by human liver microsomes using triple quadrupole mass spectrometry.
Brandon EF, van Ooijen RD, Sparidans RW, Lázaro LL, Heck AJ, Beijnen JH, Schellens JH. Brandon EF, et al. Among authors: schellens jh. J Mass Spectrom. 2005 Jun;40(6):821-31. doi: 10.1002/jms.863. J Mass Spectrom. 2005. PMID: 15892174
Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines.
Brandon EF, Bosch TM, Deenen MJ, Levink R, van der Wal E, van Meerveld JB, Bijl M, Beijnen JH, Schellens JH, Meijerman I. Brandon EF, et al. Among authors: schellens jh. Toxicol Appl Pharmacol. 2006 Feb 15;211(1):1-10. doi: 10.1016/j.taap.2005.05.004. Epub 2005 Jun 21. Toxicol Appl Pharmacol. 2006. PMID: 15975613
In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction.
Brandon EF, Meijerman I, Klijn JS, den Arend D, Sparidans RW, Lázaro LL, Beijnen JH, Schellens JH. Brandon EF, et al. Among authors: schellens jh. Anticancer Drugs. 2005 Oct;16(9):935-43. doi: 10.1097/01.cad.0000180121.16407.38. Anticancer Drugs. 2005. PMID: 16162970
In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug.
Brandon EF, Sparidans RW, Guijt KJ, Löwenthal S, Meijerman I, Beijnen JH, Schellens JH. Brandon EF, et al. Among authors: schellens jh. Invest New Drugs. 2006 Jan;24(1):3-14. doi: 10.1007/s10637-005-4538-9. Invest New Drugs. 2006. PMID: 16379042
In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug.
Brandon EF, Sparidans RW, van Ooijen RD, Meijerman I, Lazaro LL, Manzanares I, Beijnen JH, Schellens JH. Brandon EF, et al. Among authors: schellens jh. Invest New Drugs. 2007 Feb;25(1):9-19. doi: 10.1007/s10637-006-7589-7. Invest New Drugs. 2007. PMID: 16633717
Determinants of the elimination of methotrexate and 7-hydroxy-methotrexate following high-dose infusional therapy to cancer patients.
Joerger M, Huitema AD, van den Bongard HJ, Baas P, Schornagel JH, Schellens JH, Beijnen JH. Joerger M, et al. Among authors: schellens jh. Br J Clin Pharmacol. 2006 Jul;62(1):71-80. doi: 10.1111/j.1365-2125.2005.02513.x. Br J Clin Pharmacol. 2006. PMID: 16842380 Free PMC article.
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