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A phase I, open-label, randomized crossover study to assess the effect of dosing of the MEK 1/2 inhibitor Selumetinib (AZD6244; ARRY-142866) in the presence and absence of food in patients with advanced solid tumors.
Leijen S, Soetekouw PM, Jeffry Evans TR, Nicolson M, Schellens JH, Learoyd M, Grinsted L, Zazulina V, Pwint T, Middleton M. Leijen S, et al. Among authors: schellens jh. Cancer Chemother Pharmacol. 2011 Dec;68(6):1619-28. doi: 10.1007/s00280-011-1732-7. Epub 2011 Sep 28. Cancer Chemother Pharmacol. 2011. PMID: 21953275 Free PMC article. Clinical Trial.
Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut.
Bardelmeijer HA, Ouwehand M, Malingré MM, Schellens J, Beijnen JH, van Tellingen O. Bardelmeijer HA, et al. Among authors: schellens j. Cancer Chemother Pharmacol. 2002 Feb;49(2):119-25. doi: 10.1007/s00280-001-0394-2. Epub 2001 Nov 20. Cancer Chemother Pharmacol. 2002. PMID: 11862425
Urinary and fecal excretion of topotecan in patients with malignant solid tumours.
Herben VM, Schoemaker nE, Rosing H, van Zomeren DM, ten Bokkel Huinink WW, Dubbelman R, Hearn S, Schellens JH, Beijnen JH. Herben VM, et al. Among authors: schellens jh. Cancer Chemother Pharmacol. 2002 Jul;50(1):59-64. doi: 10.1007/s00280-002-0454-2. Epub 2002 Apr 5. Cancer Chemother Pharmacol. 2002. PMID: 12111113 Clinical Trial.
A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin.
Schoemaker NE, van Kesteren C, Rosing H, Jansen S, Swart M, Lieverst J, Fraier D, Breda M, Pellizzoni C, Spinelli R, Grazia Porro M, Beijnen JH, Schellens JH, ten Bokkel Huinink WW. Schoemaker NE, et al. Among authors: schellens jh. Br J Cancer. 2002 Sep 9;87(6):608-14. doi: 10.1038/sj.bjc.6600516. Br J Cancer. 2002. PMID: 12237769 Free PMC article. Clinical Trial.
889 results