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Interleukin-6 trans-signalling in chronic inflammation and cancer.
Scheller J, Ohnesorge N, Rose-John S. Scheller J, et al. Scand J Immunol. 2006 May;63(5):321-9. doi: 10.1111/j.1365-3083.2006.01750.x. Scand J Immunol. 2006. PMID: 16640655 Review.
Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition.
Scheller J, Kovaleva M, Rabe B, Eichler J, Kallen KJ, Rose-John S. Scheller J, et al. J Immunol Methods. 2004 Aug;291(1-2):93-100. doi: 10.1016/j.jim.2004.05.002. J Immunol Methods. 2004. PMID: 15345308
No inhibition of IL-27 signaling by soluble gp130.
Scheller J, Schuster B, Hölscher C, Yoshimoto T, Rose-John S. Scheller J, et al. Biochem Biophys Res Commun. 2005 Jan 28;326(4):724-8. doi: 10.1016/j.bbrc.2004.11.098. Biochem Biophys Res Commun. 2005. PMID: 15607729
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.
Stuhlmann-Laeisz C, Lang S, Chalaris A, Krzysztof P, Enge S, Eichler J, Klingmüller U, Samuel M, Ernst M, Rose-John S, Scheller J. Stuhlmann-Laeisz C, et al. Among authors: scheller j. Mol Biol Cell. 2006 Jul;17(7):2986-95. doi: 10.1091/mbc.e05-12-1129. Epub 2006 Apr 19. Mol Biol Cell. 2006. PMID: 16624864 Free PMC article.
STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice.
Mitsuyama K, Matsumoto S, Rose-John S, Suzuki A, Hara T, Tomiyasu N, Handa K, Tsuruta O, Funabashi H, Scheller J, Toyonaga A, Sata M. Mitsuyama K, et al. Among authors: scheller j. Gut. 2006 Sep;55(9):1263-9. doi: 10.1136/gut.2005.079343. Epub 2006 May 8. Gut. 2006. PMID: 16682432 Free PMC article.
METHODS: Intestinal expression of phospho-STAT3 in SAMP1/Yit mice and control AKR/J mice was examined by western blotting and immunohistochemistry. ...RESULTS: Phospho-STAT3 was expressed strongly during the disease course in SAMP1/Yit mice but only transiently in AKR/J
METHODS: Intestinal expression of phospho-STAT3 in SAMP1/Yit mice and control AKR/J mice was examined by western blotting and immunoh …
Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.
Rose-John S, Scheller J, Elson G, Jones SA. Rose-John S, et al. Among authors: scheller j. J Leukoc Biol. 2006 Aug;80(2):227-36. doi: 10.1189/jlb.1105674. Epub 2006 May 17. J Leukoc Biol. 2006. PMID: 16707558 Review.
Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling.
Lin M, Rose-John S, Grötzinger J, Conrad U, Scheller J. Lin M, et al. Among authors: scheller j. Biochem J. 2006 Sep 15;398(3):577-83. doi: 10.1042/BJ20060544. Biochem J. 2006. PMID: 16716147 Free PMC article.
Interleukin-6 and its receptor: from bench to bedside.
Scheller J, Rose-John S. Scheller J, et al. Med Microbiol Immunol. 2006 Dec;195(4):173-83. doi: 10.1007/s00430-006-0019-9. Epub 2006 May 31. Med Microbiol Immunol. 2006. PMID: 16741736 Review.
gp130 dimerization in the absence of ligand: preformed cytokine receptor complexes.
Tenhumberg S, Schuster B, Zhu L, Kovaleva M, Scheller J, Kallen KJ, Rose-John S. Tenhumberg S, et al. Among authors: scheller j. Biochem Biophys Res Commun. 2006 Aug 4;346(3):649-57. doi: 10.1016/j.bbrc.2006.05.173. Epub 2006 Jun 6. Biochem Biophys Res Commun. 2006. PMID: 16774741
Sleep enhances IL-6 trans-signaling in humans.
Dimitrov S, Lange T, Benedict C, Nowell MA, Jones SA, Scheller J, Rose-John S, Born J. Dimitrov S, et al. Among authors: scheller j. FASEB J. 2006 Oct;20(12):2174-6. doi: 10.1096/fj.06-5754fje. Epub 2006 Aug 15. FASEB J. 2006. PMID: 16912152
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