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High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise.
Zderic TW, Davidson CJ, Schenk S, Byerley LO, Coyle EF. Zderic TW, et al. Am J Physiol Endocrinol Metab. 2004 Feb;286(2):E217-25. doi: 10.1152/ajpendo.00159.2003. Epub 2003 Oct 14. Am J Physiol Endocrinol Metab. 2004. PMID: 14559721
Manipulation of dietary carbohydrate and muscle glycogen affects glucose uptake during exercise when fat oxidation is impaired by beta-adrenergic blockade.
Zderic TW, Schenk S, Davidson CJ, Byerley LO, Coyle EF. Zderic TW, et al. Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1195-201. doi: 10.1152/ajpendo.00302.2004. Epub 2004 Aug 17. Am J Physiol Endocrinol Metab. 2004. PMID: 15315908
Postexercise insulin sensitivity is not impaired after an overnight lipid infusion.
Schenk S, Cook JN, Kaufman AE, Horowitz JF. Schenk S, et al. Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E519-25. doi: 10.1152/ajpendo.00401.2004. Epub 2004 Nov 2. Am J Physiol Endocrinol Metab. 2005. PMID: 15522993 Clinical Trial.
This study's purpose was to determine whether high plasma fatty acid availability and systemic caloric excess after exercise also impair insulin sensitivity. ...
This study's purpose was to determine whether high plasma fatty acid availability and systemic caloric excess after exercise also imp …
Alterations in carbohydrate metabolism in response to short-term dietary carbohydrate restriction.
Harber MP, Schenk S, Barkan AL, Horowitz JF. Harber MP, et al. Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E306-12. doi: 10.1152/ajpendo.00069.2005. Epub 2005 Mar 29. Am J Physiol Endocrinol Metab. 2005. PMID: 15797987 Clinical Trial.
Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training.
Schenk S, Horowitz JF. Schenk S, et al. Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E254-60. doi: 10.1152/ajpendo.00051.2006. Epub 2006 May 2. Am J Physiol Endocrinol Metab. 2006. PMID: 16670153 Clinical Trial.
Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity.
Schenk S, Harber MP, Shrivastava CR, Burant CF, Horowitz JF. Schenk S, et al. J Physiol. 2009 Oct 15;587(Pt 20):4949-61. doi: 10.1113/jphysiol.2009.175489. Epub 2009 Sep 1. J Physiol. 2009. PMID: 19723783 Free PMC article.
When we artificially increased fatty acid mobilization after weight loss to pre-weight-loss levels via an overnight lipid infusion, the improvement in S(I) was almost completely reversed. Importantly, WL + EX did not protect against this lipid-induced reversal in S( …
When we artificially increased fatty acid mobilization after weight loss to pre-weight-loss levels via an overnight lipid infusion, the impr …
Energy deficit after exercise augments lipid mobilization but does not contribute to the exercise-induced increase in insulin sensitivity.
Newsom SA, Schenk S, Thomas KM, Harber MP, Knuth ND, Goldenberg N, Horowitz JF. Newsom SA, et al. J Appl Physiol (1985). 2010 Mar;108(3):554-60. doi: 10.1152/japplphysiol.01106.2009. Epub 2009 Dec 31. J Appl Physiol (1985). 2010. PMID: 20044472 Free PMC article. Clinical Trial.

The morning after exercise we obtained a muscle biopsy, assessed insulin sensitivity (S(i); intravenous glucose tolerance test) and measured lipid kinetics (isotope tracers). ...CON (402 +/- 29 vs. 540 +/- 33 mmol/kg dry wt, P < 0.01) coincided with a significant increa

The morning after exercise we obtained a muscle biopsy, assessed insulin sensitivity (S(i); intravenous glucose tolerance test) and m …
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