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Locally renewing resident synovial macrophages provide a protective barrier for the joint.
Culemann S, Grüneboom A, Nicolás-Ávila JÁ, Weidner D, Lämmle KF, Rothe T, Quintana JA, Kirchner P, Krljanac B, Eberhardt M, Ferrazzi F, Kretzschmar E, Schicht M, Fischer K, Gelse K, Faas M, Pfeifle R, Ackermann JA, Pachowsky M, Renner N, Simon D, Haseloff RF, Ekici AB, Bäuerle T, Blasig IE, Vera J, Voehringer D, Kleyer A, Paulsen F, Schett G, Hidalgo A, Krönke G. Culemann S, et al. Among authors: schett g. Nature. 2019 Aug;572(7771):670-675. doi: 10.1038/s41586-019-1471-1. Epub 2019 Aug 7. Nature. 2019. PMID: 31391580 Free PMC article.
Dickkopf-1 is a master regulator of joint remodeling.
Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G. Diarra D, et al. Among authors: schett g. Nat Med. 2007 Feb;13(2):156-63. doi: 10.1038/nm1538. Epub 2007 Jan 21. Nat Med. 2007. PMID: 17237793
The role of Wnt proteins in arthritis.
Schett G, Zwerina J, David JP. Schett G, et al. Nat Clin Pract Rheumatol. 2008 Sep;4(9):473-80. doi: 10.1038/ncprheum0881. Nat Clin Pract Rheumatol. 2008. PMID: 18756273 Review.
Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints.
Uderhardt S, Diarra D, Katzenbeisser J, David JP, Zwerina J, Richards W, Kronke G, Schett G. Uderhardt S, et al. Among authors: schett g. Ann Rheum Dis. 2010 Mar;69(3):592-7. doi: 10.1136/ard.2008.102046. Epub 2009 Mar 19. Ann Rheum Dis. 2010. PMID: 19304568
12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis.
Krönke G, Katzenbeisser J, Uderhardt S, Zaiss MM, Scholtysek C, Schabbauer G, Zarbock A, Koenders MI, Axmann R, Zwerina J, Baenckler HW, van den Berg W, Voll RE, Kühn H, Joosten LA, Schett G. Krönke G, et al. Among authors: schett g. J Immunol. 2009 Sep 1;183(5):3383-9. doi: 10.4049/jimmunol.0900327. Epub 2009 Aug 12. J Immunol. 2009. PMID: 19675173 Free article.
Treatment with DNAse I fosters binding to nec PBMC of CRP.
Janko C, Schorn C, Weidner D, Sarter K, Chaurio R, Sheriff A, Schett G, Munoz LE. Janko C, et al. Among authors: schett g. Autoimmunity. 2009 May;42(4):286-8. doi: 10.1080/08916930902828197. Autoimmunity. 2009. PMID: 19811278
1,023 results