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Hepatic mitochondrial dysfunction in nonalcoholic steatohepatitis: Read-out or reason?
Trebicka J, Schierwagen R. Trebicka J, et al. Among authors: schierwagen r. Hepatology. 2016 May;63(5):1729-32. doi: 10.1002/hep.28482. Epub 2016 Mar 18. Hepatology. 2016. PMID: 26845516 No abstract available.
Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts.
Trebicka J, Racz I, Siegmund SV, Cara E, Granzow M, Schierwagen R, Klein S, Wojtalla A, Hennenberg M, Huss S, Fischer HP, Heller J, Zimmer A, Sauerbruch T. Trebicka J, et al. Among authors: schierwagen r. Liver Int. 2011 Jul;31(6):860-70. doi: 10.1111/j.1478-3231.2011.02496.x. Epub 2011 Mar 8. Liver Int. 2011. PMID: 21645218
We analysed triglyceride and hydroxyproline contents in liver homogenates. mRNA levels of CBs, pro-inflammatory cytokines [tumour necrosis factor (TNF)-α, monocyte chemotactic protein (MCP)-1, interleukin (IL)-1β] and profibrotic factors [α-smooth muscle actin (α-SMA), procollage …
We analysed triglyceride and hydroxyproline contents in liver homogenates. mRNA levels of CBs, pro-inflammatory cytokines [tumour necrosis f …
HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects.
Klein S, Van Beuge MM, Granzow M, Beljaars L, Schierwagen R, Kilic S, Heidari I, Huss S, Sauerbruch T, Poelstra K, Trebicka J. Klein S, et al. Among authors: schierwagen r. J Hepatol. 2012 Dec;57(6):1220-7. doi: 10.1016/j.jhep.2012.07.033. Epub 2012 Aug 6. J Hepatol. 2012. PMID: 22878469
Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats.
Klein S, Klösel J, Schierwagen R, Körner C, Granzow M, Huss S, Mazar IG, Weber S, van den Ven PF, Pieper-Fürst U, Fürst DO, Nattermann J, Lammert F, Sauerbruch T, Trebicka J. Klein S, et al. Among authors: schierwagen r. Lab Invest. 2012 Oct;92(10):1440-50. doi: 10.1038/labinvest.2012.106. Epub 2012 Aug 13. Lab Invest. 2012. PMID: 22890553
Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis.
Granzow M, Schierwagen R, Klein S, Kowallick B, Huss S, Linhart M, Mazar IG, Görtzen J, Vogt A, Schildberg FA, Gonzalez-Carmona MA, Wojtalla A, Krämer B, Nattermann J, Siegmund SV, Werner N, Fürst DO, Laleman W, Knolle P, Shah VH, Sauerbruch T, Trebicka J. Granzow M, et al. Among authors: schierwagen r. Hepatology. 2014 Jul;60(1):334-48. doi: 10.1002/hep.27117. Epub 2014 May 6. Hepatology. 2014. PMID: 24619965 Free PMC article.
Expression of vasoactive proteins in gastric antral mucosa reflects vascular dysfunction in patients with cirrhosis and portal hypertension.
Trebicka J, Wix C, von Heydebrand M, Hittatiya K, Reiberger T, Klein S, Schierwagen R, Kristiansen G, Peck-Radosavljevic M, Fischer HP, Møller S, Bendtsen F, Krag A, Sauerbruch T. Trebicka J, et al. Among authors: schierwagen r. Liver Int. 2015 Apr;35(4):1393-402. doi: 10.1111/liv.12613. Epub 2014 Jul 5. Liver Int. 2015. PMID: 24912856 Clinical Trial.
Circulating microRNAs as a marker for liver injury in human immunodeficiency virus patients.
Anadol E, Schierwagen R, Elfimova N, Tack K, Schwarze-Zander C, Eischeid H, Noetel A, Boesecke C, Jansen C, Dold L, Wasmuth JC, Strassburg CP, Spengler U, Rockstroh JK, Odenthal M, Trebicka J. Anadol E, et al. Among authors: schierwagen r. Hepatology. 2015 Jan;61(1):46-55. doi: 10.1002/hep.27369. Epub 2014 Nov 20. Hepatology. 2015. PMID: 25125218
Circulating Elastin Fragments Are Not Affected by Hepatic, Renal and Hemodynamic Changes, But Reflect Survival in Cirrhosis with TIPS.
Nielsen MJ, Lehmann J, Leeming DJ, Schierwagen R, Klein S, Jansen C, Strassburg CP, Bendtsen F, Møller S, Sauerbruch T, Karsdal MA, Krag A, Trebicka J. Nielsen MJ, et al. Among authors: schierwagen r. Dig Dis Sci. 2015 Nov;60(11):3456-64. doi: 10.1007/s10620-015-3783-9. Epub 2015 Jul 3. Dig Dis Sci. 2015. PMID: 26138655
Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis.
Schierwagen R, Maybüchen L, Zimmer S, Hittatiya K, Bäck C, Klein S, Uschner FE, Reul W, Boor P, Nickenig G, Strassburg CP, Trautwein C, Plat J, Lütjohann D, Sauerbruch T, Tacke F, Trebicka J. Schierwagen R, et al. Sci Rep. 2015 Aug 11;5:12931. doi: 10.1038/srep12931. Sci Rep. 2015. PMID: 26263022 Free PMC article.
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