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A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
Rempel E, Hoelting L, Waldmann T, Balmer NV, Schildknecht S, Grinberg M, Das Gaspar JA, Shinde V, Stöber R, Marchan R, van Thriel C, Liebing J, Meisig J, Blüthgen N, Sachinidis A, Rahnenführer J, Hengstler JG, Leist M. Rempel E, et al. Among authors: schildknecht s. Arch Toxicol. 2015 Sep;89(9):1599-618. doi: 10.1007/s00204-015-1573-y. Epub 2015 Aug 14. Arch Toxicol. 2015. PMID: 26272509 Free PMC article.
Food for thought... on the real success of 3R approaches.
Leist M, Kadereit S, Schildknecht S. Leist M, et al. Among authors: schildknecht s. ALTEX. 2008;25(1):17-32. doi: 10.14573/altex.2008.1.17. ALTEX. 2008. PMID: 18360724 Free article. English, German. No abstract available.
Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+).
Krug AK, Gutbier S, Zhao L, Pöltl D, Kullmann C, Ivanova V, Förster S, Jagtap S, Meiser J, Leparc G, Schildknecht S, Adam M, Hiller K, Farhan H, Brunner T, Hartung T, Sachinidis A, Leist M. Krug AK, et al. Among authors: schildknecht s. Cell Death Dis. 2014 May 8;5(5):e1222. doi: 10.1038/cddis.2014.166. Cell Death Dis. 2014. PMID: 24810058 Free PMC article.
67 results