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The 76-gene signature defines high-risk patients that benefit from adjuvant tamoxifen therapy.
Zhang Y, Sieuwerts AM, McGreevy M, Casey G, Cufer T, Paradiso A, Harbeck N, Span PN, Hicks DG, Crowe J, Tubbs RR, Budd GT, Lyons J, Sweep FC, Schmitt M, Schittulli F, Golouh R, Talantov D, Wang Y, Foekens JA. Zhang Y, et al. Among authors: schittulli f. Breast Cancer Res Treat. 2009 Jul;116(2):303-9. doi: 10.1007/s10549-008-0183-2. Epub 2008 Sep 23. Breast Cancer Res Treat. 2009. PMID: 18821012 Clinical Trial.
Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer.
Foekens JA, Atkins D, Zhang Y, Sweep FC, Harbeck N, Paradiso A, Cufer T, Sieuwerts AM, Talantov D, Span PN, Tjan-Heijnen VC, Zito AF, Specht K, Hoefler H, Golouh R, Schittulli F, Schmitt M, Beex LV, Klijn JG, Wang Y. Foekens JA, et al. Among authors: schittulli f. J Clin Oncol. 2006 Apr 10;24(11):1665-71. doi: 10.1200/JCO.2005.03.9115. Epub 2006 Feb 27. J Clin Oncol. 2006. PMID: 16505412
DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients--Technical and clinical validation in a multi-centre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group.
Maier S, Nimmrich I, Koenig T, Eppenberger-Castori S, Bohlmann I, Paradiso A, Spyratos F, Thomssen C, Mueller V, Nährig J, Schittulli F, Kates R, Lesche R, Schwope I, Kluth A, Marx A, Martens JW, Foekens JA, Schmitt M, Harbeck N; European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group. Maier S, et al. Among authors: schittulli f. Eur J Cancer. 2007 Jul;43(11):1679-86. doi: 10.1016/j.ejca.2007.04.025. Epub 2007 Jun 29. Eur J Cancer. 2007. PMID: 17601725
Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers.
Yau C, Fedele V, Roydasgupta R, Fridlyand J, Hubbard A, Gray JW, Chew K, Dairkee SH, Moore DH, Schittulli F, Tommasi S, Paradiso A, Albertson DG, Benz CC. Yau C, et al. Among authors: schittulli f. Breast Cancer Res. 2007;9(5):R59. doi: 10.1186/bcr1765. Breast Cancer Res. 2007. PMID: 17850661 Free PMC article.
Randomized phase III trial of adjuvant epirubicin followed by cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) versus CMF followed by epirubicin in patients with node-negative or 1-3 node-positive rapidly proliferating breast cancer.
Amadori D, Silvestrini R, De Lena M, Boccardo F, Rocca A, Scarpi E, Schittulli F, Brandi M, Maltoni R, Serra P, Ponzone R, Biglia N, Gianni L, Tienghi A, Valerio MR, Bonginelli P, Amaducci L, Faedi M, Baldini E, Paradiso A. Amadori D, et al. Among authors: schittulli f. Breast Cancer Res Treat. 2011 Feb;125(3):775-84. doi: 10.1007/s10549-010-1257-5. Epub 2010 Dec 4. Breast Cancer Res Treat. 2011. PMID: 21132360 Free article. Clinical Trial.
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