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Focal adhesion kinase: in command and control of cell motility.
Mitra SK, Hanson DA, Schlaepfer DD. Mitra SK, et al. Nat Rev Mol Cell Biol. 2005 Jan;6(1):56-68. doi: 10.1038/nrm1549. Nat Rev Mol Cell Biol. 2005. PMID: 15688067 Review.
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis.
Barbero S, Mielgo A, Torres V, Teitz T, Shields DJ, Mikolon D, Bogyo M, Barilà D, Lahti JM, Schlaepfer D, Stupack DG. Barbero S, et al. Cancer Res. 2009 May 1;69(9):3755-63. doi: 10.1158/0008-5472.CAN-08-3937. Epub 2009 Apr 21. Cancer Res. 2009. PMID: 19383910 Free PMC article.
alpha(v)beta3-integrin-dependent activation of focal adhesion kinase mediates NF-kappaB activation and motogenic activity by HIV-1 Tat in endothelial cells.
Urbinati C, Bugatti A, Giacca M, Schlaepfer D, Presta M, Rusnati M. Urbinati C, et al. J Cell Sci. 2005 Sep 1;118(Pt 17):3949-58. doi: 10.1242/jcs.02518. Epub 2005 Aug 16. J Cell Sci. 2005. PMID: 16105876
Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression.
Yurdagul A Jr, Sulzmaier FJ, Chen XL, Pattillo CB, Schlaepfer DD, Orr AW. Yurdagul A Jr, et al. Among authors: schlaepfer dd. J Cell Sci. 2016 Apr 15;129(8):1580-91. doi: 10.1242/jcs.182097. Epub 2016 Feb 18. J Cell Sci. 2016. PMID: 26906414 Free PMC article.
Adaptive Resistance to Chemotherapy, A Multi-FAK-torial Linkage.
Taylor KN, Schlaepfer DD. Taylor KN, et al. Among authors: schlaepfer dd. Mol Cancer Ther. 2018 Apr;17(4):719-723. doi: 10.1158/1535-7163.MCT-17-1177. Mol Cancer Ther. 2018. PMID: 29610281 Free PMC article.
Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.
Masià-Balagué M, Izquierdo I, Garrido G, Cordomí A, Pérez-Benito L, Miller NL, Schlaepfer DD, Gigoux V, Aragay AM. Masià-Balagué M, et al. J Biol Chem. 2015 Jun 12;290(24):15197-209. doi: 10.1074/jbc.M114.628164. Epub 2015 Apr 28. J Biol Chem. 2015. PMID: 25922072 Free PMC article.
FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth.
Tancioni I, Miller NL, Uryu S, Lawson C, Jean C, Chen XL, Kleinschmidt EG, Schlaepfer DD. Tancioni I, et al. Breast Cancer Res. 2015 Mar 28;17:47. doi: 10.1186/s13058-015-0551-x. Breast Cancer Res. 2015. PMID: 25880415 Free PMC article.
FAK in cancer: mechanistic findings and clinical applications.
Sulzmaier FJ, Jean C, Schlaepfer DD. Sulzmaier FJ, et al. Nat Rev Cancer. 2014 Sep;14(9):598-610. doi: 10.1038/nrc3792. Epub 2014 Aug 7. Nat Rev Cancer. 2014. PMID: 25098269 Free PMC article. Review.
FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth.
Tancioni I, Uryu S, Sulzmaier FJ, Shah NR, Lawson C, Miller NL, Jean C, Chen XL, Ward KK, Schlaepfer DD. Tancioni I, et al. Mol Cancer Ther. 2014 Aug;13(8):2050-61. doi: 10.1158/1535-7163.MCT-13-1063. Epub 2014 Jun 4. Mol Cancer Ther. 2014. PMID: 24899686 Free PMC article.
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