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The influence of pulmonary surfactant on nanoparticulate drug delivery systems.
Schleh C, Rothen-Rutishauser B, Kreyling WG. Schleh C, et al. Eur J Pharm Biopharm. 2011 Apr;77(3):350-2. doi: 10.1016/j.ejpb.2010.12.025. Epub 2010 Dec 31. Eur J Pharm Biopharm. 2011. PMID: 21195761
Interaction of nanoparticles with the pulmonary surfactant system.
Schleh C, Hohlfeld JM. Schleh C, et al. Inhal Toxicol. 2009 Jul;21 Suppl 1:97-103. doi: 10.1080/08958370903005744. Inhal Toxicol. 2009. PMID: 19558240 Review.
The effect of titanium dioxide nanoparticles on pulmonary surfactant function and ultrastructure.
Schleh C, Mühlfeld C, Pulskamp K, Schmiedl A, Nassimi M, Lauenstein HD, Braun A, Krug N, Erpenbeck VJ, Hohlfeld JM. Schleh C, et al. Respir Res. 2009 Sep 30;10(1):90. doi: 10.1186/1465-9921-10-90. Respir Res. 2009. PMID: 19793393 Free PMC article.
A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung.
Nassimi M, Schleh C, Lauenstein HD, Hussein R, Hoymann HG, Koch W, Pohlmann G, Krug N, Sewald K, Rittinghausen S, Braun A, Müller-Goymann C. Nassimi M, et al. Eur J Pharm Biopharm. 2010 Jun;75(2):107-16. doi: 10.1016/j.ejpb.2010.02.014. Epub 2010 Mar 3. Eur J Pharm Biopharm. 2010. PMID: 20206256
The in vivo effects were determined in a 16-day repeated-dose inhalation toxicity study using female BALB/c mice, which were daily exposed to different concentrations of SLN30 aerosols (1-200 microg deposit dose). ...
The in vivo effects were determined in a 16-day repeated-dose inhalation toxicity study using female BALB/c mice, which were daily ex …
Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection.
Lipka J, Semmler-Behnke M, Sperling RA, Wenk A, Takenaka S, Schleh C, Kissel T, Parak WJ, Kreyling WG. Lipka J, et al. Biomaterials. 2010 Sep;31(25):6574-81. doi: 10.1016/j.biomaterials.2010.05.009. Epub 2010 Jun 9. Biomaterials. 2010. PMID: 20542560
Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration.
Hirn S, Semmler-Behnke M, Schleh C, Wenk A, Lipka J, Schäffler M, Takenaka S, Möller W, Schmid G, Simon U, Kreyling WG. Hirn S, et al. Eur J Pharm Biopharm. 2011 Apr;77(3):407-16. doi: 10.1016/j.ejpb.2010.12.029. Epub 2010 Dec 31. Eur J Pharm Biopharm. 2011. PMID: 21195759 Free PMC article.
Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration.
Schleh C, Semmler-Behnke M, Lipka J, Wenk A, Hirn S, Schäffler M, Schmid G, Simon U, Kreyling WG. Schleh C, et al. Nanotoxicology. 2012 Feb;6(1):36-46. doi: 10.3109/17435390.2011.552811. Epub 2011 Feb 10. Nanotoxicology. 2012. PMID: 21309618 Free PMC article.
Surfactant Protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model.
Schleh C, Rothen-Rutishauser BM, Blank F, Lauenstein HD, Nassimi M, Krug N, Braun A, Erpenbeck VJ, Gehr P, Hohlfeld JM. Schleh C, et al. Respir Res. 2012 Feb 1;13(1):8. doi: 10.1186/1465-9921-13-8. Respir Res. 2012. PMID: 22296755 Free PMC article.
Biodistribution of inhaled gold nanoparticles in mice and the influence of surfactant protein D.
Schleh C, Holzwarth U, Hirn S, Wenk A, Simonelli F, Schäffler M, Möller W, Gibson N, Kreyling WG. Schleh C, et al. J Aerosol Med Pulm Drug Deliv. 2013 Feb;26(1):24-30. doi: 10.1089/jamp.2011.0951. Epub 2012 Aug 2. J Aerosol Med Pulm Drug Deliv. 2013. PMID: 22856532
Pulmonary surfactant is indispensable in order to simulate the in vivo situation.
Schleh C, Kreyling WG, Lehr CM. Schleh C, et al. Part Fibre Toxicol. 2013 Mar 25;10:6. doi: 10.1186/1743-8977-10-6. Part Fibre Toxicol. 2013. PMID: 23531298 Free PMC article.
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