Schlick T - Search Results

1

Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization.

Wang Y, Schlick T. Wang Y, et al. Among authors: schlick t. J Am Chem Soc. 2008 Oct 8;130(40):13240-50. doi: 10.1021/ja802215c. Epub 2008 Sep 12. J Am Chem Soc. 2008. PMID: 18785738 Free PMC article.

2

Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase beta's closing.

Radhakrishnan R, Schlick T. Radhakrishnan R, et al. Among authors: schlick t. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5970-5. doi: 10.1073/pnas.0308585101. Epub 2004 Apr 6. Proc Natl Acad Sci U S A. 2004. PMID: 15069184 Free PMC article.

3

Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly.

Yang L, Arora K, Beard WA, Wilson SH, Schlick T. Yang L, et al. Among authors: schlick t. J Am Chem Soc. 2004 Jul 14;126(27):8441-53. doi: 10.1021/ja049412o. J Am Chem Soc. 2004. PMID: 15238001

4

In silico evidence for DNA polymerase-beta's substrate-induced conformational change.

Arora K, Schlick T. Arora K, et al. Among authors: schlick t. Biophys J. 2004 Nov;87(5):3088-99. doi: 10.1529/biophysj.104.040915. Biophys J. 2004. PMID: 15507687 Free PMC article.

5

Fidelity discrimination in DNA polymerase beta: differing closing profiles for a mismatched (G:A) versus matched (G:C) base pair.

Radhakrishnan R, Schlick T. Radhakrishnan R, et al. Among authors: schlick t. J Am Chem Soc. 2005 Sep 28;127(38):13245-52. doi: 10.1021/ja052623o. J Am Chem Soc. 2005. PMID: 16173754 Free PMC article.

6

Mismatch-induced conformational distortions in polymerase beta support an induced-fit mechanism for fidelity.

Arora K, Beard WA, Wilson SH, Schlick T. Arora K, et al. Among authors: schlick t. Biochemistry. 2005 Oct 11;44(40):13328-41. doi: 10.1021/bi0507682. Biochemistry. 2005. PMID: 16201758

7

Subtle but variable conformational rearrangements in the replication cycle of Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) may accommodate lesion bypass.

Wang Y, Arora K, Schlick T. Wang Y, et al. Among authors: schlick t. Protein Sci. 2006 Jan;15(1):135-51. doi: 10.1110/ps.051726906. Epub 2005 Dec 1. Protein Sci. 2006. PMID: 16322565 Free PMC article.

8

Conformational transition pathway of polymerase beta/DNA upon binding correct incoming substrate.

Arora K, Schlick T. Arora K, et al. Among authors: schlick t. J Phys Chem B. 2005 Mar 24;109(11):5358-67. doi: 10.1021/jp0446377. J Phys Chem B. 2005. PMID: 16863202

The order of the events and the intermediate states during pol beta's closing pathway are identified and compared to a separate study of pol beta using transition path sampling (TPS) (Radhakrishnan, R.; Schlick, T. Proc. Natl. Acad. Sci. USA 2004, 101, 5970-5975). R …

The order of the events and the intermediate states during pol beta's closing pathway are identified and compared to a separate study of pol …

9

Sequential side-chain residue motions transform the binary into the ternary state of DNA polymerase lambda.

Foley MC, Arora K, Schlick T. Foley MC, et al. Among authors: schlick t. Biophys J. 2006 Nov 1;91(9):3182-95. doi: 10.1529/biophysj.106.092080. Epub 2006 Aug 18. Biophys J. 2006. PMID: 16920835 Free PMC article.

10

Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection.

Radhakrishnan R, Arora K, Wang Y, Beard WA, Wilson SH, Schlick T. Radhakrishnan R, et al. Among authors: schlick t. Biochemistry. 2006 Dec 26;45(51):15142-56. doi: 10.1021/bi061353z. Epub 2006 Dec 1. Biochemistry. 2006. PMID: 17176036 Free PMC article. Review.

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