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The moderate affinity of clozapine at H3 receptors is not shared by its two major metabolites and by structurally related and unrelated atypical neuroleptics.
Schlicker E, Marr I. Schlicker E, et al. Naunyn Schmiedebergs Arch Pharmacol. 1996 Feb;353(3):290-4. doi: 10.1007/BF00168630. Naunyn Schmiedebergs Arch Pharmacol. 1996. PMID: 8692283
The present study shows that five atypical neuroleptics of different chemical classes and the two major metabolites of clozapine possess a lower affinity and/or antagonistic potency at H3 receptors than clozapine itself (pKi 6.15, pA2 6.33; Kathmann M, Schlicker E, …
The present study shows that five atypical neuroleptics of different chemical classes and the two major metabolites of clozapine possess a l …
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