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Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-1 trials.
Coxeter PD, Schluter PJ, Eastwood HL, Nikles CJ, Glasziou PP. Coxeter PD, et al. Complement Ther Med. 2003 Dec;11(4):215-22. doi: 10.1016/s0965-2299(03)00122-5. Complement Ther Med. 2003. PMID: 15022653 Clinical Trial.
Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials.
Yelland MJ, Nikles CJ, McNairn N, Del Mar CB, Schluter PJ, Brown RM. Yelland MJ, et al. Rheumatology (Oxford). 2007 Jan;46(1):135-40. doi: 10.1093/rheumatology/kel195. Epub 2006 Jun 15. Rheumatology (Oxford). 2007. PMID: 16777855 Clinical Trial.
Aggregating single patient (n-of-1) trials in populations where recruitment and retention was difficult: the case of palliative care.
Nikles J, Mitchell GK, Schluter P, Good P, Hardy J, Rowett D, Shelby-James T, Vohra S, Currow D. Nikles J, et al. J Clin Epidemiol. 2011 May;64(5):471-80. doi: 10.1016/j.jclinepi.2010.05.009. Epub 2010 Oct 8. J Clin Epidemiol. 2011. PMID: 20933365 Review.
A series of n-of-1 trials of stimulants in brain injured children.
Nikles J, Mitchell G, McKinlay L, Waugh MC, Epps A, Carmont SA, Schluter PJ, Lloyd O, Senior H. Nikles J, et al. NeuroRehabilitation. 2017;40(1):11-21. doi: 10.3233/NRE-161386. NeuroRehabilitation. 2017. PMID: 27814302 Clinical Trial.
Using N-of-1 trials to improve patient management and save costs.
Scuffham PA, Nikles J, Mitchell GK, Yelland MJ, Vine N, Poulos CJ, Pillans PI, Bashford G, del Mar C, Schluter PJ, Glasziou P. Scuffham PA, et al. J Gen Intern Med. 2010 Sep;25(9):906-13. doi: 10.1007/s11606-010-1352-7. Epub 2010 Apr 13. J Gen Intern Med. 2010. PMID: 20386995 Free PMC article. Clinical Trial.
N-of-1 randomized trials to assess the efficacy of gabapentin for chronic neuropathic pain.
Yelland MJ, Poulos CJ, Pillans PI, Bashford GM, Nikles CJ, Sturtevant JM, Vine N, Del Mar CB, Schluter PJ, Tan M, Chan J, Mackenzie F, Brown R. Yelland MJ, et al. Pain Med. 2009 May-Jun;10(4):754-61. doi: 10.1111/j.1526-4637.2009.00615.x. Epub 2009 Apr 22. Pain Med. 2009. PMID: 19453961 Clinical Trial.
Single patient (n-of-1) trials with binary treatment preference.
Schluter PJ, Ware RS. Schluter PJ, et al. Stat Med. 2005 Sep 15;24(17):2625-36. doi: 10.1002/sim.2132. Stat Med. 2005. PMID: 16118811
Central nervous system stimulants for secondary attention deficit-hyperactivity disorder after paediatric traumatic brain injury: a rationale and protocol for single patient (n-of-1) multiple cross-over trials.
Senior HE, McKinlay L, Nikles J, Schluter PJ, Carmont SA, Waugh MC, Epps A, Lloyd O, Mitchell GK. Senior HE, et al. BMC Pediatr. 2013 May 28;13:89. doi: 10.1186/1471-2431-13-89. BMC Pediatr. 2013. PMID: 23710976 Free PMC article. Clinical Trial.
Prolotherapy injections, saline injections, and exercises for chronic low-back pain: a randomized trial.
Yelland MJ, Glasziou PP, Bogduk N, Schluter PJ, McKernon M. Yelland MJ, et al. Spine (Phila Pa 1976). 2004 Jan 1;29(1):9-16; discussion 16. doi: 10.1097/01.BRS.0000105529.07222.5B. Spine (Phila Pa 1976). 2004. PMID: 14699269 Clinical Trial.
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