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Computational design of anti-CRISPR proteins with improved inhibition potency.
Mathony J, Harteveld Z, Schmelas C, Upmeier Zu Belzen J, Aschenbrenner S, Sun W, Hoffmann MD, Stengl C, Scheck A, Georgeon S, Rosset S, Wang Y, Grimm D, Eils R, Correia BE, Niopek D. Mathony J, et al. Among authors: schmelas c. Nat Chem Biol. 2020 Jul;16(7):725-730. doi: 10.1038/s41589-020-0518-9. Epub 2020 Apr 13. Nat Chem Biol. 2020. PMID: 32284602
Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9.
Bubeck F, Hoffmann MD, Harteveld Z, Aschenbrenner S, Bietz A, Waldhauer MC, Börner K, Fakhiri J, Schmelas C, Dietz L, Grimm D, Correia BE, Eils R, Niopek D. Bubeck F, et al. Among authors: schmelas c. Nat Methods. 2018 Nov;15(11):924-927. doi: 10.1038/s41592-018-0178-9. Epub 2018 Oct 30. Nat Methods. 2018. PMID: 30377362
Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening.
Börner K, Kienle E, Huang LY, Weinmann J, Sacher A, Bayer P, Stüllein C, Fakhiri J, Zimmermann L, Westhaus A, Beneke J, Beil N, Wiedtke E, Schmelas C, Miltner D, Rau A, Erfle H, Kräusslich HG, Müller M, Agbandje-McKenna M, Grimm D. Börner K, et al. Among authors: schmelas c. Mol Ther. 2020 Apr 8;28(4):1016-1032. doi: 10.1016/j.ymthe.2020.02.009. Epub 2020 Feb 13. Mol Ther. 2020. PMID: 32105604 Free PMC article.
Backbone circularization of Bacillus subtilis family 11 xylanase increases its thermostability and its resistance against aggregation.
Waldhauer MC, Schmitz SN, Ahlmann-Eltze C, Gleixner JG, Schmelas CC, Huhn AG, Bunne C, Büscher M, Horn M, Klughammer N, Kreft J, Schäfer E, Bayer PA, Krämer SG, Neugebauer J, Wehler P, Mayer MP, Eils R, Di Ventura B. Waldhauer MC, et al. Among authors: schmelas cc. Mol Biosyst. 2015 Dec;11(12):3231-43. doi: 10.1039/c5mb00341e. Mol Biosyst. 2015. PMID: 26434634
Overcoming MET-mediated resistance in oncogene-driven NSCLC.
Reischmann N, Schmelas C, Molina-Vila MÁ, Jordana-Ariza N, Kuntze D, García-Roman S, Simard MA, Musch D, Esdar C, Albers J, Karachaliou N. Reischmann N, et al. Among authors: schmelas c. iScience. 2023 May 29;26(7):107006. doi: 10.1016/j.isci.2023.107006. eCollection 2023 Jul 21. iScience. 2023. PMID: 37534190 Free PMC article.