Schmidt A - Search Results

1

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

Hutt DM, Herman D, Rodrigues AP, Noel S, Pilewski JM, Matteson J, Hoch B, Kellner W, Kelly JW, Schmidt A, Thomas PJ, Matsumura Y, Skach WR, Gentzsch M, Riordan JR, Sorscher EJ, Okiyoneda T, Yates JR 3rd, Lukacs GL, Frizzell RA, Manning G, Gottesfeld JM, Balch WE. Hutt DM, et al. Among authors: schmidt a. Nat Chem Biol. 2010 Jan;6(1):25-33. doi: 10.1038/nchembio.275. Epub 2009 Dec 6. Nat Chem Biol. 2010. PMID: 19966789 Free PMC article.

2

Biochemical and biophysical approaches to probe CFTR structure.

Schmidt A, Mendoza JL, Thomas PJ. Schmidt A, et al. Methods Mol Biol. 2011;741:365-76. doi: 10.1007/978-1-61779-117-8_24. Methods Mol Biol. 2011. PMID: 21594797 Free PMC article.

3

Introduction to section IV: biophysical methods to approach CFTR structure.

Mendoza JL, Schmidt A, Thomas PJ. Mendoza JL, et al. Among authors: schmidt a. Methods Mol Biol. 2011;741:321-7. doi: 10.1007/978-1-61779-117-8_21. Methods Mol Biol. 2011. PMID: 21594794 Free PMC article.

4

Solubilizing mutations used to crystallize one CFTR domain attenuate the trafficking and channel defects caused by the major cystic fibrosis mutation.

Pissarra LS, Farinha CM, Xu Z, Schmidt A, Thibodeau PH, Cai Z, Thomas PJ, Sheppard DN, Amaral MD. Pissarra LS, et al. Among authors: schmidt a. Chem Biol. 2008 Jan;15(1):62-9. doi: 10.1016/j.chembiol.2007.11.012. Chem Biol. 2008. PMID: 18215773

5

The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domain.

Hoelen H, Kleizen B, Schmidt A, Richardson J, Charitou P, Thomas PJ, Braakman I. Hoelen H, et al. Among authors: schmidt a. PLoS One. 2010 Nov 30;5(11):e15458. doi: 10.1371/journal.pone.0015458. PLoS One. 2010. PMID: 21152102 Free PMC article.

6

Requirements for efficient correction of ΔF508 CFTR revealed by analyses of evolved sequences.

Mendoza JL, Schmidt A, Li Q, Nuvaga E, Barrett T, Bridges RJ, Feranchak AP, Brautigam CA, Thomas PJ. Mendoza JL, et al. Among authors: schmidt a. Cell. 2012 Jan 20;148(1-2):164-74. doi: 10.1016/j.cell.2011.11.023. Cell. 2012. PMID: 22265409 Free PMC article.

7

Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms.

Roxo-Rosa M, Xu Z, Schmidt A, Neto M, Cai Z, Soares CM, Sheppard DN, Amaral MD. Roxo-Rosa M, et al. Among authors: schmidt a. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17891-6. doi: 10.1073/pnas.0608312103. Epub 2006 Nov 10. Proc Natl Acad Sci U S A. 2006. PMID: 17098864 Free PMC article.

8

Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator.

Schmidt A, Hughes LK, Cai Z, Mendes F, Li H, Sheppard DN, Amaral MD. Schmidt A, et al. Br J Pharmacol. 2008 Mar;153(6):1311-23. doi: 10.1038/sj.bjp.0707663. Epub 2008 Jan 28. Br J Pharmacol. 2008. PMID: 18223673 Free PMC article.

9

Strategies to investigate the mechanism of action of CFTR modulators.

Cai Z, Scott-Ward TS, Li H, Schmidt A, Sheppard DN. Cai Z, et al. Among authors: schmidt a. J Cyst Fibros. 2004 Aug;3 Suppl 2:141-7. doi: 10.1016/j.jcf.2004.05.030. J Cyst Fibros. 2004. PMID: 15463947 Free article. Review.

10

Direct block of the cystic fibrosis transmembrane conductance regulator Cl(-) channel by niflumic acid.

Scott-Ward TS, Li H, Schmidt A, Cai Z, Sheppard DN. Scott-Ward TS, et al. Among authors: schmidt a. Mol Membr Biol. 2004 Jan-Feb;21(1):27-38. doi: 10.1080/09687680310001597758. Mol Membr Biol. 2004. PMID: 14668136

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