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Regulation of angiogenesis by oxygen and metabolism.
Fraisl P, Mazzone M, Schmidt T, Carmeliet P. Fraisl P, et al. Dev Cell. 2009 Feb;16(2):167-79. doi: 10.1016/j.devcel.2009.01.003. Dev Cell. 2009. PMID: 19217420 Review.
Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia.
Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P. Schmidt T, et al. Cancer Cell. 2011 Jun 14;19(6):740-53. doi: 10.1016/j.ccr.2011.05.007. Cancer Cell. 2011. PMID: 21665148
Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.
Van de Veire S, Stalmans I, Heindryckx F, Oura H, Tijeras-Raballand A, Schmidt T, Loges S, Albrecht I, Jonckx B, Vinckier S, Van Steenkiste C, Tugues S, Rolny C, De Mol M, Dettori D, Hainaud P, Coenegrachts L, Contreres JO, Van Bergen T, Cuervo H, Xiao WH, Le Henaff C, Buysschaert I, Kharabi Masouleh B, Geerts A, Schomber T, Bonnin P, Lambert V, Haustraete J, Zacchigna S, Rakic JM, Jiménez W, Noël A, Giacca M, Colle I, Foidart JM, Tobelem G, Morales-Ruiz M, Vilar J, Maxwell P, Vinores SA, Carmeliet G, Dewerchin M, Claesson-Welsh L, Dupuy E, Van Vlierberghe H, Christofori G, Mazzone M, Detmar M, Collen D, Carmeliet P. Van de Veire S, et al. Cell. 2010 Apr 2;141(1):178-90. doi: 10.1016/j.cell.2010.02.039. Cell. 2010. PMID: 20371353
Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.
Loges S, Schmidt T, Tjwa M, van Geyte K, Lievens D, Lutgens E, Vanhoutte D, Borgel D, Plaisance S, Hoylaerts M, Luttun A, Dewerchin M, Jonckx B, Carmeliet P. Loges S, et al. Blood. 2010 Mar 18;115(11):2264-73. doi: 10.1182/blood-2009-06-228684. Epub 2009 Nov 20. Blood. 2010. PMID: 19965679
Genetics, epigenetics and pharmaco-(epi)genomics in angiogenesis.
Buysschaert I, Schmidt T, Roncal C, Carmeliet P, Lambrechts D. Buysschaert I, et al. J Cell Mol Med. 2008 Dec;12(6B):2533-51. doi: 10.1111/j.1582-4934.2008.00515.x. J Cell Mol Med. 2008. PMID: 19210754 Free PMC article. Review.
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
Mazzone M, Dettori D, de Oliveira RL, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, de Almodovar CR, De Smet F, Vinckier S, Aragonés J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P, Carmeliet P. Mazzone M, et al. Cell. 2009 Mar 6;136(5):839-851. doi: 10.1016/j.cell.2009.01.020. Epub 2009 Feb 12. Cell. 2009. PMID: 19217150 Free PMC article.
"Antimyeloangiogenic" therapy for cancer by inhibiting PlGF.
Loges S, Schmidt T, Carmeliet P. Loges S, et al. Clin Cancer Res. 2009 Jun 1;15(11):3648-53. doi: 10.1158/1078-0432.CCR-08-2276. Epub 2009 May 26. Clin Cancer Res. 2009. PMID: 19470735 Review.
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.
Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK. Snuderl M, et al. Cell. 2013 Feb 28;152(5):1065-76. doi: 10.1016/j.cell.2013.01.036. Cell. 2013. PMID: 23452854 Free PMC article.
(±)-trans-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: Synthesis, in vitro evaluation and SAR analysis.
Bernal FA, Gerhards M, Kaiser M, Wünsch B, Schmidt TJ. Bernal FA, et al. Among authors: schmidt tj. Eur J Med Chem. 2020 Jul 23;205:112493. doi: 10.1016/j.ejmech.2020.112493. Online ahead of print. Eur J Med Chem. 2020. PMID: 32745819
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