Schmitt LT - Search Results

1

Prediction of designer-recombinases for DNA editing with generative deep learning.

Schmitt LT, Paszkowski-Rogacz M, Jug F, Buchholz F. Schmitt LT, et al. Nat Commun. 2022 Dec 27;13(1):7966. doi: 10.1038/s41467-022-35614-6. Nat Commun. 2022. PMID: 36575171 Free PMC article.

2

CRISPR/Cas9 as a tool to dissect cancer mutations.

Sayed S, Paszkowski-Rogacz M, Schmitt LT, Buchholz F. Sayed S, et al. Among authors: schmitt lt. Methods. 2019 Jul 15;164-165:36-48. doi: 10.1016/j.ymeth.2019.05.007. Epub 2019 May 10. Methods. 2019. PMID: 31078796 Free article.

3

A heterodimer of evolved designer-recombinases precisely excises a human genomic DNA locus.

Lansing F, Paszkowski-Rogacz M, Schmitt LT, Schneider PM, Rojo Romanos T, Sonntag J, Buchholz F. Lansing F, et al. Among authors: schmitt lt. Nucleic Acids Res. 2020 Jan 10;48(1):472-485. doi: 10.1093/nar/gkz1078. Nucleic Acids Res. 2020. PMID: 31745551 Free PMC article.

4

Pairing of single mutations yields obligate Cre-type site-specific recombinases.

Hoersten J, Ruiz-Gómez G, Lansing F, Rojo-Romanos T, Schmitt LT, Sonntag J, Pisabarro MT, Buchholz F. Hoersten J, et al. Among authors: schmitt lt. Nucleic Acids Res. 2022 Jan 25;50(2):1174-1186. doi: 10.1093/nar/gkab1240. Nucleic Acids Res. 2022. PMID: 34951450 Free PMC article.

5

Correction of a Factor VIII genomic inversion with designer-recombinases.

Lansing F, Mukhametzyanova L, Rojo-Romanos T, Iwasawa K, Kimura M, Paszkowski-Rogacz M, Karpinski J, Grass T, Sonntag J, Schneider PM, Günes C, Hoersten J, Schmitt LT, Rodriguez-Muela N, Knöfler R, Takebe T, Buchholz F. Lansing F, et al. Among authors: schmitt lt. Nat Commun. 2022 Jan 20;13(1):422. doi: 10.1038/s41467-022-28080-7. Nat Commun. 2022. PMID: 35058465 Free PMC article.

6

DNA methylation-independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins.

Ding L, Schmitt LT, Brux M, Sürün D, Augsburg M, Lansing F, Mircetic J, Theis M, Buchholz F. Ding L, et al. Among authors: schmitt lt. Life Sci Alliance. 2022 Mar 14;5(6):e202101321. doi: 10.26508/lsa.202101321. Print 2022 Jun. Life Sci Alliance. 2022. PMID: 35288457 Free PMC article.

7

Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing.

Sayed S, Sidorova OA, Hennig A, Augsburg M, Cortés Vesga CP, Abohawya M, Schmitt LT, Sürün D, Stange DE, Mircetic J, Buchholz F. Sayed S, et al. Among authors: schmitt lt. Cancer Res. 2022 Sep 2;82(17):3002-3015. doi: 10.1158/0008-5472.CAN-21-2519. Cancer Res. 2022. PMID: 35802645 Free PMC article.

8

Discovery and characterization of novel Cre-type tyrosine site-specific recombinases for advanced genome engineering.

Jelicic M, Schmitt LT, Paszkowski-Rogacz M, Walder A, Schubert N, Hoersten J, Sürün D, Buchholz F. Jelicic M, et al. Among authors: schmitt lt. Nucleic Acids Res. 2023 May 9;51(10):5285-97. doi: 10.1093/nar/gkad366. Online ahead of print. Nucleic Acids Res. 2023. PMID: 37158248 Free PMC article.

9

Quantification of evolved DNA-editing enzymes at scale with DEQSeq.

Schmitt LT, Schneider A, Posorski J, Lansing F, Jelicic M, Jain M, Sayed S, Buchholz F, Sürün D. Schmitt LT, et al. Genome Biol. 2023 Nov 6;24(1):254. doi: 10.1186/s13059-023-03097-3. Genome Biol. 2023. PMID: 37932818 Free PMC article.

10

Activation of recombinases at specific DNA loci by zinc-finger domain insertions.

Mukhametzyanova L, Schmitt LT, Torres-Rivera J, Rojo-Romanos T, Lansing F, Paszkowski-Rogacz M, Hollak H, Brux M, Augsburg M, Schneider PM, Buchholz F. Mukhametzyanova L, et al. Among authors: schmitt lt. Nat Biotechnol. 2024 Jan 31. doi: 10.1038/s41587-023-02121-y. Online ahead of print. Nat Biotechnol. 2024. PMID: 38297187

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