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The direct route: a simplified pathway for protein import into the mitochondrion of trypanosomes.
Schneider A, Bursać D, Lithgow T. Schneider A, et al. Trends Cell Biol. 2008 Jan;18(1):12-8. doi: 10.1016/j.tcb.2007.09.009. Trends Cell Biol. 2008. PMID: 18068984 Review.
Trypanosoma brucei is a unicellular eukaryote that causes the deadly human African trypanosomiasis ('sleeping sickness') in humans. The parasite has a complicated lifestyle, it developmentally changes aspects of its mitochondrial function as it alternates from forms …
Trypanosoma brucei is a unicellular eukaryote that causes the deadly human African trypanosomiasis ('sleeping sickness') in humans. T …
Mitochondrial inner membrane protease I of saccharomyces cerevisiae.
Schneider A. Schneider A. Methods Cell Biol. 1991;34:401-7. doi: 10.1016/s0091-679x(08)61694-5. Methods Cell Biol. 1991. PMID: 1943814 Review. No abstract available.
Spectrin-like proteins in the paraflagellar rod structure of Trypanosoma brucei.
Schneider A, Lutz HU, Marugg R, Gehr P, Seebeck T. Schneider A, et al. J Cell Sci. 1988 Jun;90 ( Pt 2):307-15. J Cell Sci. 1988. PMID: 3073166
A polyclonal, monospecific rabbit antibody to human erythrocyte spectrins cross-reacted with two sets of proteins (a doublet of 180/200K and a triplet of 67-66-65K; K = 10(3) Mr) in the parasitic protozoon Trypanosoma brucei brucei. ...
A polyclonal, monospecific rabbit antibody to human erythrocyte spectrins cross-reacted with two sets of proteins (a doublet o
Distinct localization and cell cycle dependence of COOH terminally tyrosinolated alpha-tubulin in the microtubules of Trypanosoma brucei brucei.
Sherwin T, Schneider A, Sasse R, Seebeck T, Gull K. Sherwin T, et al. Among authors: schneider a. J Cell Biol. 1987 Mar;104(3):439-46. doi: 10.1083/jcb.104.3.439. J Cell Biol. 1987. PMID: 3546334 Free PMC article.
Trypanosomes contain a number of microtubular structures: the flagellar axoneme; the subpellicular layer of singlet microtubules which are closely associated with the cell membrane; the basal bodies; and a cytoplasmic pool of soluble tubulin. ...This localization is …
Trypanosomes contain a number of microtubular structures: the flagellar axoneme; the subpellicular layer of singlet microtubules whic …
Subpellicular and flagellar microtubules of Trypanosoma brucei brucei contain the same alpha-tubulin isoforms.
Schneider A, Sherwin T, Sasse R, Russell DG, Gull K, Seebeck T. Schneider A, et al. J Cell Biol. 1987 Mar;104(3):431-8. doi: 10.1083/jcb.104.3.431. J Cell Biol. 1987. PMID: 3818788 Free PMC article.
The cytoskeleton of the parasitic hemoflagellate Trypanosoma brucei brucei essentially consists of two microtubule-based structures: a subpellicular layer of singlet microtubules, which are in close contact with the cell membrane, and the flagellar axoneme. In addition, th …
The cytoskeleton of the parasitic hemoflagellate Trypanosoma brucei brucei essentially consists of two microtubule-based structures: a
tRNAs are imported into mitochondria of Trypanosoma brucei independently of their genomic context and genetic origin.
Hauser R, Schneider A. Hauser R, et al. Among authors: schneider a. EMBO J. 1995 Sep 1;14(17):4212-20. EMBO J. 1995. PMID: 7556062 Free PMC article.
Three tRNA genes were tested in this system: (i) a mutated version of the trypanosomal tRNA(Tyr); (ii) a cytosolic tRNA(His) of yeast; and (iii) a human cytosolic tRNA(Lys). ...We independently confirmed the mitochondrial import of the yeast tRNA(His), since …
Three tRNA genes were tested in this system: (i) a mutated version of the trypanosomal tRNA(Tyr); (ii) a cytosolic tRNA(His) o …
Cytosolic yeast tRNA(His) is covalently modified when imported into mitochondria of Trypanosoma brucei.
Schneider A. Schneider A. Nucleic Acids Res. 1996 Apr 1;24(7):1225-8. doi: 10.1093/nar/24.7.1225. Nucleic Acids Res. 1996. PMID: 8614623 Free PMC article.
The only difference found between mitochondrial and cytosolic isotypes of the tRNAs are mitochondria-specific nucleotide modifications which appear to be a common feature of imported tRNAs in trypanosomes. In this study, a mutated yeast cytosolic tRNAHis was express …
The only difference found between mitochondrial and cytosolic isotypes of the tRNAs are mitochondria-specific nucleotide modifications which …
In vitro import of proteins into mitochondria of Trypanosoma brucei and Leishmania tarentolae.
Hauser R, Pypaert M, Häusler T, Horn EK, Schneider A. Hauser R, et al. Among authors: schneider a. J Cell Sci. 1996 Feb;109 ( Pt 2):517-23. J Cell Sci. 1996. PMID: 8838675
Isotonic cell lysis followed by equilibrium density centrifugation in Nycodenz gradients yielded mitochondrial fractions exhibiting a membrane potential. ...Energy-dependent uptake of an artificial precursor protein, containing a trypanosomal presequence attached to …
Isotonic cell lysis followed by equilibrium density centrifugation in Nycodenz gradients yielded mitochondrial fractions exhibiting a
In vivo import of unspliced tRNATyr containing synthetic introns of variable length into mitochondria of Leishmania tarentolae.
Sbicego S, Nabholz CE, Hauser R, Blum B, Schneider A. Sbicego S, et al. Among authors: schneider a. Nucleic Acids Res. 1998 Dec 1;26(23):5251-5. doi: 10.1093/nar/26.23.5251. Nucleic Acids Res. 1998. PMID: 9826745 Free PMC article.
In this study we have used the splicing-deficient tRNATyr as a vehicle to introduce foreign sequences into the mitochondrion of Leishmania tarentolae. ...Whereas stable expression of precursor tRNAsTyr was obtained for introns up to a length of 76 nt, only precursor …
In this study we have used the splicing-deficient tRNATyr as a vehicle to introduce foreign sequences into the mitochondrion of Leish …
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