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Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells.
Koehler MF, Bergeron P, Blackwood EM, Bowman K, Clark KR, Firestein R, Kiefer JR, Maskos K, McCleland ML, Orren L, Salphati L, Schmidt S, Schneider EV, Wu J, Beresini MH. Koehler MF, et al. Among authors: schneider ev. ACS Med Chem Lett. 2016 Jan 6;7(3):223-8. doi: 10.1021/acsmedchemlett.5b00278. eCollection 2016 Mar 10. ACS Med Chem Lett. 2016. PMID: 26985305 Free PMC article.
Structure-kinetic relationship study of CDK8/CycC specific compounds.
Schneider EV, Böttcher J, Huber R, Maskos K, Neumann L. Schneider EV, et al. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8081-6. doi: 10.1073/pnas.1305378110. Epub 2013 Apr 29. Proc Natl Acad Sci U S A. 2013. PMID: 23630251 Free PMC article.
Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8.
Bergeron P, Koehler MF, Blackwood EM, Bowman K, Clark K, Firestein R, Kiefer JR, Maskos K, McCleland ML, Orren L, Ramaswamy S, Salphati L, Schmidt S, Schneider EV, Wu J, Beresini M. Bergeron P, et al. Among authors: schneider ev. ACS Med Chem Lett. 2016 Apr 5;7(6):595-600. doi: 10.1021/acsmedchemlett.6b00044. eCollection 2016 Jun 9. ACS Med Chem Lett. 2016. PMID: 27326333 Free PMC article.
A precisely positioned MED12 activation helix stimulates CDK8 kinase activity.
Klatt F, Leitner A, Kim IV, Ho-Xuan H, Schneider EV, Langhammer F, Weinmann R, Müller MR, Huber R, Meister G, Kuhn CD. Klatt F, et al. Among authors: schneider ev. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2894-2905. doi: 10.1073/pnas.1917635117. Epub 2020 Jan 27. Proc Natl Acad Sci U S A. 2020. PMID: 31988137 Free PMC article.
Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
Pelish HE, Liau BB, Nitulescu II, Tangpeerachaikul A, Poss ZC, Da Silva DH, Caruso BT, Arefolov A, Fadeyi O, Christie AL, Du K, Banka D, Schneider EV, Jestel A, Zou G, Si C, Ebmeier CC, Bronson RT, Krivtsov AV, Myers AG, Kohl NE, Kung AL, Armstrong SA, Lemieux ME, Taatjes DJ, Shair MD. Pelish HE, et al. Among authors: schneider ev. Nature. 2015 Oct 8;526(7572):273-276. doi: 10.1038/nature14904. Epub 2015 Sep 28. Nature. 2015. PMID: 26416749 Free PMC article.
Cryo-EM Structures of CRAF2/14-3-32 and CRAF2/14-3-32/MEK12 Complexes.
Dedden D, Nitsche J, Schneider EV, Thomsen M, Schwarz D, Leuthner B, Grädler U. Dedden D, et al. Among authors: schneider ev. J Mol Biol. 2024 Mar 15;436(6):168483. doi: 10.1016/j.jmb.2024.168483. Epub 2024 Feb 7. J Mol Biol. 2024. PMID: 38331211
16 results