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Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions.
Linden AM, Greene SJ, Bergeron M, Schoepp DD. Linden AM, et al. Among authors: schoepp dd. Neuropsychopharmacology. 2004 Mar;29(3):502-13. doi: 10.1038/sj.npp.1300321. Neuropsychopharmacology. 2004. PMID: 14694349
In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders.
Rorick-Kehn LM, Johnson BG, Knitowski KM, Salhoff CR, Witkin JM, Perry KW, Griffey KI, Tizzano JP, Monn JA, McKinzie DL, Schoepp DD. Rorick-Kehn LM, et al. Among authors: schoepp dd. Psychopharmacology (Berl). 2007 Jul;193(1):121-36. doi: 10.1007/s00213-007-0758-3. Epub 2007 Mar 24. Psychopharmacology (Berl). 2007. PMID: 17384937
Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039).
Fell MJ, Svensson KA, Johnson BG, Schoepp DD. Fell MJ, et al. Among authors: schoepp dd. J Pharmacol Exp Ther. 2008 Jul;326(1):209-17. doi: 10.1124/jpet.108.136861. Epub 2008 Apr 18. J Pharmacol Exp Ther. 2008. PMID: 18424625 Free article.
The metabotropic glutamate (mGLU)2/3 receptor antagonist LY341495 [2S-2-amino-2-(1S,2S-2-carboxycyclopropyl-1-yl)-3-(xanth-9-yl)propanoic acid] stimulates waking and fast electroencephalogram power and blocks the effects of the mGLU2/3 receptor agonist ly379268 [(-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate] in rats.
Feinberg I, Schoepp DD, Hsieh KC, Darchia N, Campbell IG. Feinberg I, et al. Among authors: schoepp dd. J Pharmacol Exp Ther. 2005 Feb;312(2):826-33. doi: 10.1124/jpet.104.076547. Epub 2004 Sep 21. J Pharmacol Exp Ther. 2005. PMID: 15383637
186 results