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How malaria modulates memory: activation and dysregulation of B cells in Plasmodium infection.
Scholzen A, Sauerwein RW. Scholzen A, et al. Trends Parasitol. 2013 May;29(5):252-62. doi: 10.1016/j.pt.2013.03.002. Epub 2013 Apr 4. Trends Parasitol. 2013. PMID: 23562778 Review.
Humoral immune responses play a major role in naturally acquired immunity to malaria, but are slow to develop and ineffectively maintained. ...We propose a model of how the parasite may mediate these effects by direct interaction with B cells via the cysteine-rich i …
Humoral immune responses play a major role in naturally acquired immunity to malaria, but are slow to develop and ineffectively maint …
Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta.
Scholzen A, Mittag D, Rogerson SJ, Cooke BM, Plebanski M. Scholzen A, et al. PLoS Pathog. 2009 Aug;5(8):e1000543. doi: 10.1371/journal.ppat.1000543. Epub 2009 Aug 14. PLoS Pathog. 2009. PMID: 19680449 Free PMC article.
Using a co-culture system of malaria-infected red blood cells (iRBCs) and peripheral blood mononuclear cells from healthy individuals, we found that two populations of Foxp3(hi) and Foxp3(int) CD4(+)CD25(hi) T cells with a typical Treg phenotype (CTLA-4(+), CD127(lo …
Using a co-culture system of malaria-infected red blood cells (iRBCs) and peripheral blood mononuclear cells from healthy individuals …
Heroes or villains? T regulatory cells in malaria infection.
Scholzen A, Minigo G, Plebanski M. Scholzen A, et al. Trends Parasitol. 2010 Jan;26(1):16-25. doi: 10.1016/j.pt.2009.10.004. Epub 2009 Nov 13. Trends Parasitol. 2010. PMID: 19914134 Review.
Infection with Plasmodium parasites can cause severe disease due to a lack of protective immune responses to clear parasitemia, or to the host's inability to control excessive inflammation resulting in immunopathology. ...
Infection with Plasmodium parasites can cause severe disease due to a lack of protective immune responses to clear parasitemia, or to …
Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans.
Teirlinck AC, McCall MB, Roestenberg M, Scholzen A, Woestenenk R, de Mast Q, van der Ven AJ, Hermsen CC, Luty AJ, Sauerwein RW. Teirlinck AC, et al. Among authors: scholzen a. PLoS Pathog. 2011 Dec;7(12):e1002389. doi: 10.1371/journal.ppat.1002389. Epub 2011 Dec 1. PLoS Pathog. 2011. PMID: 22144890 Free PMC article. Clinical Trial.
We show that cellular responses to both PfSpz and PfRBC are induced and remain almost undiminished up to 14 months after even a single malaria episode. ...These data demonstrate that cellular responses can be readily induced and are long-lived following infection with P. f …
We show that cellular responses to both PfSpz and PfRBC are induced and remain almost undiminished up to 14 months after even a singl …
Comparison of clinical and parasitological data from controlled human malaria infection trials.
Roestenberg M, O'Hara GA, Duncan CJ, Epstein JE, Edwards NJ, Scholzen A, van der Ven AJ, Hermsen CC, Hill AV, Sauerwein RW. Roestenberg M, et al. Among authors: scholzen a. PLoS One. 2012;7(6):e38434. doi: 10.1371/journal.pone.0038434. Epub 2012 Jun 11. PLoS One. 2012. PMID: 22701640 Free PMC article.
Results were compared to a report from the US Military Malaria Vaccine Program. RESULTS: We show that controlled human malaria infection trials are safe and demonstrate a consistent safety profile with minor differences in the frequencies of arthralgia, fatigue, chi …
Results were compared to a report from the US Military Malaria Vaccine Program. RESULTS: We show that controlled human malaria infect …
Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites.
Roestenberg M, Bijker EM, Sim BKL, Billingsley PF, James ER, Bastiaens GJH, Teirlinck AC, Scholzen A, Teelen K, Arens T, van der Ven AJAM, Gunasekera A, Chakravarty S, Velmurugan S, Hermsen CC, Sauerwein RW, Hoffman SL. Roestenberg M, et al. Among authors: scholzen a. Am J Trop Med Hyg. 2013 Jan;88(1):5-13. doi: 10.4269/ajtmh.2012.12-0613. Epub 2012 Nov 13. Am J Trop Med Hyg. 2013. PMID: 23149582 Free PMC article. Clinical Trial.
Controlled human malaria infection with sporozoites is a standardized and powerful tool for evaluation of malaria vaccine and drug efficacy but so far only applied by exposure to bites of Plasmodium falciparum (Pf)-infected mosquitoes. ...
Controlled human malaria infection with sporozoites is a standardized and powerful tool for evaluation of malaria vaccine and drug ef …
NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infections.
Teirlinck AC, Roestenberg M, van de Vegte-Bolmer M, Scholzen A, Heinrichs MJ, Siebelink-Stoter R, Graumans W, van Gemert GJ, Teelen K, Vos MW, Nganou-Makamdop K, Borrmann S, Rozier YP, Erkens MA, Luty AJ, Hermsen CC, Sim BK, van Lieshout L, Hoffman SL, Visser LG, Sauerwein RW. Teirlinck AC, et al. Among authors: scholzen a. J Infect Dis. 2013 Feb 15;207(4):656-60. doi: 10.1093/infdis/jis725. Epub 2012 Nov 27. J Infect Dis. 2013. PMID: 23186785 Free PMC article. Clinical Trial.
We established a new field clone of Plasmodium falciparum for use in controlled human malaria infections and vaccine studies to complement the current small portfolio of P. falciparum strains, primarily based on NF54. ...In a controlled human malaria infection trial …
We established a new field clone of Plasmodium falciparum for use in controlled human malaria infections and vaccine studies to compl …
Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.
Bijker EM, Bastiaens GJ, Teirlinck AC, van Gemert GJ, Graumans W, van de Vegte-Bolmer M, Siebelink-Stoter R, Arens T, Teelen K, Nahrendorf W, Remarque EJ, Roeffen W, Jansens A, Zimmerman D, Vos M, van Schaijk BC, Wiersma J, van der Ven AJ, de Mast Q, van Lieshout L, Verweij JJ, Hermsen CC, Scholzen A, Sauerwein RW. Bijker EM, et al. Among authors: scholzen a. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7862-7. doi: 10.1073/pnas.1220360110. Epub 2013 Apr 18. Proc Natl Acad Sci U S A. 2013. PMID: 23599283 Free PMC article.
Twenty-five malaria-naïve volunteers were enrolled in a clinical trial, 15 of whom received CPS immunization. Five immunized subjects and five controls received a sporozoite challenge by mosquito bites, whereas nine immunized and five control subjects received an i. …
Twenty-five malaria-naïve volunteers were enrolled in a clinical trial, 15 of whom received CPS immunization. Five immunized subjects …
BAFF and BAFF receptor levels correlate with B cell subset activation and redistribution in controlled human malaria infection.
Scholzen A, Teirlinck AC, Bijker EM, Roestenberg M, Hermsen CC, Hoffman SL, Sauerwein RW. Scholzen A, et al. J Immunol. 2014 Apr 15;192(8):3719-29. doi: 10.4049/jimmunol.1302960. Epub 2014 Mar 19. J Immunol. 2014. PMID: 24646735 Free PMC article.
BAFF is a key cytokine in B cell homeostasis, but its potential contribution to the modulation of the blood B cell pool during malaria remains elusive. ...This provides unique evidence for a link between malaria-induced immune activation and temporary expansion of t …
BAFF is a key cytokine in B cell homeostasis, but its potential contribution to the modulation of the blood B cell pool during malari …
Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum.
Behet MC, Foquet L, van Gemert GJ, Bijker EM, Meuleman P, Leroux-Roels G, Hermsen CC, Scholzen A, Sauerwein RW. Behet MC, et al. Among authors: scholzen a. Malar J. 2014 Apr 5;13:136. doi: 10.1186/1475-2875-13-136. Malar J. 2014. PMID: 24708526 Free PMC article.
The functionality of these antibodies was assessed in vitro in gliding and human hepatocyte traversal assays, and in vivo in a human liver-chimeric mouse model. RESULTS: Whereas pre-treatment of sporozoites with 2 mg/ml IgG in the majority of the volunteers did not have an …
The functionality of these antibodies was assessed in vitro in gliding and human hepatocyte traversal assays, and in vivo in a human …
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