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Determination of the phospholipid precursor of anandamide and other N-acylethanolamine phospholipids before and after sodium azide-induced toxicity in cultured neocortical neurons.
Hansen HH, Hansen SH, Schousboe A, Hansen HS. Hansen HH, et al. J Neurochem. 2000 Aug;75(2):861-71. doi: 10.1046/j.1471-4159.2000.0750861.x. J Neurochem. 2000. PMID: 10899965
This may suggest the presence of a putative stereoisomer of the anandamide precursor with at least one trans-configured double bond in the N-arachidonoyl moiety. These results show that with the present method, neuronal NAPE species can be identified and quantified with re …
This may suggest the presence of a putative stereoisomer of the anandamide precursor with at least one trans-configured double bond i …
Effects of inhibitors of protein synthesis and intracellular transport on the gamma-aminobutyric acid agonist-induced functional differentiation of cultured cerebellar granule cells.
Belhage B, Hansen GH, Meier E, Schousboe A. Belhage B, et al. J Neurochem. 1990 Oct;55(4):1107-13. doi: 10.1111/j.1471-4159.1990.tb03112.x. J Neurochem. 1990. PMID: 2168931
These experiments were performed to differentiate between an intracellular and a plasma membrane localization of the receptors. ...
These experiments were performed to differentiate between an intracellular and a plasma membrane localization of the receptors. ...
Glutamate neurotransmission is affected in prenatally stressed offspring.
Adrover E, Pallarés ME, Baier CJ, Monteleone MC, Giuliani FA, Waagepetersen HS, Brocco MA, Cabrera R, Sonnewald U, Schousboe A, Antonelli MC. Adrover E, et al. Neurochem Int. 2015 Sep;88:73-87. doi: 10.1016/j.neuint.2015.05.005. Epub 2015 May 27. Neurochem Int. 2015. PMID: 26026592
These offspring also showed long-lasting astroglial hypertrophy and a reduced dendritic arborization with synaptic loss. Since metabolism of glutamate is dependent on interactions between neurons and surrounding astroglia, our results suggest that glutamate neurotransmitte …
These offspring also showed long-lasting astroglial hypertrophy and a reduced dendritic arborization with synaptic loss. Since metabo …
Expression of glutamine transporter isoforms in cerebral cortex of rats with chronic hepatic encephalopathy.
Leke R, Escobar TD, Rao KV, Silveira TR, Norenberg MD, Schousboe A. Leke R, et al. Neurochem Int. 2015 Sep;88:32-7. doi: 10.1016/j.neuint.2015.03.005. Epub 2015 Apr 1. Neurochem Int. 2015. PMID: 25842041
Hepatic encephalopathy (HE) is a neuropsychiatric disorder that occurs due to acute and chronic liver diseases, the hallmark of which is the increased levels of ammonia and subsequent alterations in glutamine synthesis, i.e. conditions associated with the pathophysiology o …
Hepatic encephalopathy (HE) is a neuropsychiatric disorder that occurs due to acute and chronic liver diseases, the hallmark of which …
Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons.
Lund TM, Risa O, Sonnewald U, Schousboe A, Waagepetersen HS. Lund TM, et al. J Neurochem. 2009 Jul;110(1):80-91. doi: 10.1111/j.1471-4159.2009.06115.x. Epub 2009 May 18. J Neurochem. 2009. PMID: 19457063
Ketone bodies serve as alternative energy substrates for the brain in cases of low glucose availability such as during starvation or in patients treated with a ketogenic diet. ...Our results suggest that the change in aspartate-glutamate homeostasis is due to a decr …
Ketone bodies serve as alternative energy substrates for the brain in cases of low glucose availability such as during starvation or in pati …
A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS.
Clausen RP, Frølund B, Larsson OM, Schousboe A, Krogsgaard-Larsen P, White HS. Clausen RP, et al. Neurochem Int. 2006 May-Jun;48(6-7):637-42. doi: 10.1016/j.neuint.2005.12.031. Epub 2006 Mar 3. Neurochem Int. 2006. PMID: 16517017 Review.
This novel pharmacological profile among GABA uptake inhibitors prompted a thorough investigation of the in vivo properties of this compound. These investigations have for the first time demonstrated a functional role for GABA transporter subtype GAT2/BGT-1, which p …
This novel pharmacological profile among GABA uptake inhibitors prompted a thorough investigation of the in vivo properties of this c …
Lipid raft localization of GABA A receptor and Na+, K+-ATPase in discrete microdomain clusters in rat cerebellar granule cells.
Dalskov SM, Immerdal L, Niels-Christiansen LL, Hansen GH, Schousboe A, Danielsen EM. Dalskov SM, et al. Neurochem Int. 2005 May;46(6):489-99. doi: 10.1016/j.neuint.2004.11.010. Neurochem Int. 2005. PMID: 15769551
The microdomain localization of the GABA(A) receptor in rat cerebellar granule cells was studied by subcellular fractionation and fluorescence- and immunogold electron microscopy. ...In contrast, both the GABA(A) receptor and Na(+), K(+)-ATPase were largely soluble …
The microdomain localization of the GABA(A) receptor in rat cerebellar granule cells was studied by subcellular fractionation and flu …
Mutational studies using a cation-conducting GABAA receptor reveal the selectivity determinants of the Cys-loop family of ligand-gated ion channels.
Jensen ML, Pedersen LN, Timmermann DB, Schousboe A, Ahring PK. Jensen ML, et al. J Neurochem. 2005 Feb;92(4):962-72. doi: 10.1111/j.1471-4159.2004.02970.x. J Neurochem. 2005. PMID: 15686498
The present study evaluates how four key amino acid residue positions (- 4' to - 1') within the M1-M2 linker of the GABA(A) receptor beta subunit influences ion selectivity of a cation-conducting GABA receptor. ...The critical factor for cation selectivity was the p …
The present study evaluates how four key amino acid residue positions (- 4' to - 1') within the M1-M2 linker of the GABA(A) receptor …
Charge selectivity of the Cys-loop family of ligand-gated ion channels.
Jensen ML, Schousboe A, Ahring PK. Jensen ML, et al. J Neurochem. 2005 Jan;92(2):217-25. doi: 10.1111/j.1471-4159.2004.02883.x. J Neurochem. 2005. PMID: 15663470 Review.
The determinants of charge selectivity of the Cys-loop family of ligand-gated ion channels have been studied for more than a decade. ...Only recently, the determinants of charge selectivity of heteromeric receptors have been addressed for the GABA(A) receptor alpha2 …
The determinants of charge selectivity of the Cys-loop family of ligand-gated ion channels have been studied for more than a decade. …
First direct demonstration of extensive GABA synthesis in mouse cerebellar neuronal cultures.
Sonnewald U, Olstad E, Qu H, Babot Z, Cristòfol R, Suñol C, Schousboe A, Waagepetersen H. Sonnewald U, et al. J Neurochem. 2004 Nov;91(4):796-803. doi: 10.1111/j.1471-4159.2004.02794.x. J Neurochem. 2004. PMID: 15525333
Cultures of neocortical neurones (predominantly GABAergic) had under similar conditions a GABA content and labelling of 32 +/- 2 nmol/mg protein and 21 +/- 2%. The cerebellar cultures contained only 6% glutamate decarboxylase (GAD)-positive neurones when immunolabelled usi …
Cultures of neocortical neurones (predominantly GABAergic) had under similar conditions a GABA content and labelling of 32 +/- 2 nmol …
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