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Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis.
Benveniste H, Drejer J, Schousboe A, Diemer NH. Benveniste H, et al. Among authors: schousboe a. J Neurochem. 1984 Nov;43(5):1369-74. doi: 10.1111/j.1471-4159.1984.tb05396.x. J Neurochem. 1984. PMID: 6149259
Rats were implanted with 0.3-mm-diameter dialysis tubing through the hippocampus and subsequently perfused with Ringer's solution at a flow rate of 2 microliter/min. ...Samples were collected before, during, and after a 10-min period of transient complete cerebral i …
Rats were implanted with 0.3-mm-diameter dialysis tubing through the hippocampus and subsequently perfused with Ringer's solution at a
The glutamatergic synapse in Aghia pelagia: the spirit of Wierzba moves south.
Albrecht J, Schousboe A, Plaitakis A. Albrecht J, et al. Among authors: schousboe a. Neurochem Int. 2012 Sep;61(4):443. doi: 10.1016/j.neuint.2012.06.005. Epub 2012 Jun 26. Neurochem Int. 2012. PMID: 22743192 No abstract available.
Glutamate neurotransmission is affected in prenatally stressed offspring.
Adrover E, Pallarés ME, Baier CJ, Monteleone MC, Giuliani FA, Waagepetersen HS, Brocco MA, Cabrera R, Sonnewald U, Schousboe A, Antonelli MC. Adrover E, et al. Among authors: schousboe a. Neurochem Int. 2015 Sep;88:73-87. doi: 10.1016/j.neuint.2015.05.005. Epub 2015 May 27. Neurochem Int. 2015. PMID: 26026592
These offspring also showed long-lasting astroglial hypertrophy and a reduced dendritic arborization with synaptic loss. Since metabolism of glutamate is dependent on interactions between neurons and surrounding astroglia, our results suggest that glutamate neurotransmitte …
These offspring also showed long-lasting astroglial hypertrophy and a reduced dendritic arborization with synaptic loss. Since metabo …
Expression of glutamine transporter isoforms in cerebral cortex of rats with chronic hepatic encephalopathy.
Leke R, Escobar TD, Rao KV, Silveira TR, Norenberg MD, Schousboe A. Leke R, et al. Among authors: schousboe a. Neurochem Int. 2015 Sep;88:32-7. doi: 10.1016/j.neuint.2015.03.005. Epub 2015 Apr 1. Neurochem Int. 2015. PMID: 25842041
Hepatic encephalopathy (HE) is a neuropsychiatric disorder that occurs due to acute and chronic liver diseases, the hallmark of which is the increased levels of ammonia and subsequent alterations in glutamine synthesis, i.e. conditions associated with the pathophysiology o …
Hepatic encephalopathy (HE) is a neuropsychiatric disorder that occurs due to acute and chronic liver diseases, the hallmark of which …
Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons.
Lund TM, Risa O, Sonnewald U, Schousboe A, Waagepetersen HS. Lund TM, et al. Among authors: schousboe a. J Neurochem. 2009 Jul;110(1):80-91. doi: 10.1111/j.1471-4159.2009.06115.x. Epub 2009 May 18. J Neurochem. 2009. PMID: 19457063
Ketone bodies serve as alternative energy substrates for the brain in cases of low glucose availability such as during starvation or in patients treated with a ketogenic diet. ...Our results suggest that the change in aspartate-glutamate homeostasis is due to a decr …
Ketone bodies serve as alternative energy substrates for the brain in cases of low glucose availability such as during starvation or in pati …
Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools.
Sonnewald U, Kortner TM, Qu H, Olstad E, Suñol C, Bak LK, Schousboe A, Waagepetersen HS. Sonnewald U, et al. Among authors: schousboe a. Neurochem Int. 2006 May-Jun;48(6-7):572-8. doi: 10.1016/j.neuint.2006.01.005. Epub 2006 Mar 3. Neurochem Int. 2006. PMID: 16516347
Synthesis of GABA after 1 week in culture, when the enzymatic machinery is considered to be at a more differentiated level, was shown by labeling from [U-(13)C]glutamine added on day 7. ...In conclusion, the present study shows that GABA synthesis is taking place via GAD i …
Synthesis of GABA after 1 week in culture, when the enzymatic machinery is considered to be at a more differentiated level, was shown …
Effects of thiopental on transport and metabolism of glutamate in cultured cerebellar granule neurons.
Qu H, Waagepetersen HS, van Hengel M, Wolt S, Dale O, Unsgård G, Sletvold O, Schousboe A, Sonnewald U. Qu H, et al. Among authors: schousboe a. Neurochem Int. 2000 Aug-Sep;37(2-3):207-15. doi: 10.1016/s0197-0186(00)00024-3. Neurochem Int. 2000. PMID: 10812206
Since barbiturates are known to bind to the GABA(A) receptor, some experiments were carried out in the presence of GABA. Cerebellar granule neurons were incubated for 2 h in medium containing 0.25 mM [U-(13)C]glutamate, 3 mM glucose, 50 microM GABA and 0.1 or 1 mM thiopent …
Since barbiturates are known to bind to the GABA(A) receptor, some experiments were carried out in the presence of GABA. Cerebellar g …
NMR spectroscopic study of cell cultures of astrocytes and neurons exposed to hypoxia: compartmentation of astrocyte metabolism.
Sonnewald U, Müller TB, Westergaard N, Unsgård G, Petersen SB, Schousboe A. Sonnewald U, et al. Among authors: schousboe a. Neurochem Int. 1994 May;24(5):473-83. doi: 10.1016/0197-0186(94)90095-7. Neurochem Int. 1994. PMID: 7647701
Astrocytes were reoxygenated for 17 h after hypoxia or normoxia in a medium containing [2-13C]acetate in order to access if astrocytes were still capable of supplying neurons with essential precursors. ...
Astrocytes were reoxygenated for 17 h after hypoxia or normoxia in a medium containing [2-13C]acetate in order to access if astrocyte …
GDNF pre-treatment aggravates neuronal cell loss in oxygen-glucose deprived hippocampal slice cultures: a possible effect of glutamate transporter up-regulation.
Bonde C, Sarup A, Schousboe A, Gegelashvili G, Noraberg J, Zimmer J. Bonde C, et al. Among authors: schousboe a. Neurochem Int. 2003 Sep-Oct;43(4-5):381-8. doi: 10.1016/s0197-0186(03)00025-1. Neurochem Int. 2003. PMID: 12742082
Differential roles of alanine in GABAergic and glutamatergic neurons.
Schousboe A, Sonnewald U, Waagepetersen HS. Schousboe A, et al. Neurochem Int. 2003 Sep-Oct;43(4-5):311-5. doi: 10.1016/s0197-0186(03)00017-2. Neurochem Int. 2003. PMID: 12742074 Review.
From a functional point of view this may well be the case in a GABAergic synapse since theoretically alanine can be utilized as a metabolic fuel in GABAergic neurons where the GABA shunt is operating. ...In a glutamatergic synapse in which the large de …
From a functional point of view this may well be the case in a GABAergic synapse since theoretically alanine can be utilized a …
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