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A study of medial pallidotomy for Parkinson's disease: clinical outcome, MRI location and complications.
Samuel M, Caputo E, Brooks DJ, Schrag A, Scaravilli T, Branston NM, Rothwell JC, Marsden CD, Thomas DG, Lees AJ, Quinn NP. Samuel M, et al. Brain. 1998 Jan;121 ( Pt 1):59-75. doi: 10.1093/brain/121.1.59. Brain. 1998. PMID: 9549488
Motor performance was assessed with subset categories of the Unified Parkinson's Disease Rating Scale (UPDRS), timed motor tests and a standard dyskinesia rating scale. ...All patients were re-assessed 3 months postoperatively and a subgroup (n = 9) have so far also …
Motor performance was assessed with subset categories of the Unified Parkinson's Disease Rating Scale (UPDRS), timed motor tests and a
Clinical usefulness of magnetic resonance imaging in multiple system atrophy.
Schrag A, Kingsley D, Phatouros C, Mathias CJ, Lees AJ, Daniel SE, Quinn NP. Schrag A, et al. J Neurol Neurosurg Psychiatry. 1998 Jul;65(1):65-71. doi: 10.1136/jnnp.65.1.65. J Neurol Neurosurg Psychiatry. 1998. PMID: 9667563 Free PMC article.
RESULTS: On both 0.5 and 1.5 T scans the following items had high specificity but low sensitivity: putaminal atrophy, a hyperintense putaminal rim, and infratentorial signal change. ...Finding any of the described abnormalities on MRI gave a positive predictive valu …
RESULTS: On both 0.5 and 1.5 T scans the following items had high specificity but low sensitivity: putaminal atrophy, a hyperintense …
Young-onset Parkinson's disease revisited--clinical features, natural history, and mortality.
Schrag A, Ben-Shlomo Y, Brown R, Marsden CD, Quinn N. Schrag A, et al. Mov Disord. 1998 Nov;13(6):885-94. doi: 10.1002/mds.870130605. Mov Disord. 1998. PMID: 9827611
The authors report on clinical features and mortality rates in a group of 149 patients with apparent idiopathic parkinsonism starting before the age of 40 years. ...Fifty percent of the JP group had a positive family history of parkinsonism in a first-degree …
The authors report on clinical features and mortality rates in a group of 149 patients with apparent idiopathic parkinsonism starting …
Reduction of Parkinsonian signs in patients with Parkinson's disease by dopaminergic versus anticholinergic single-dose challenges.
Schrag A, Schelosky L, Scholz U, Poewe W. Schrag A, et al. Mov Disord. 1999 Mar;14(2):252-5. doi: 10.1002/1531-8257(199903)14:2<252::aid-mds1009>3.0.co;2-n. Mov Disord. 1999. PMID: 10091618 Clinical Trial.
We investigated the effect of an anticholinergic (biperiden) and a dopamine agonist (apomorphine) on tremor, rigidity, and akinesia in patients with idiopathic Parkinson's disease. In a standardized, crossover study design 17 patients received single-dose challenges …
We investigated the effect of an anticholinergic (biperiden) and a dopamine agonist (apomorphine) on tremor, rigidity, and akinesia i …
Atypical and typical cranial dystonia following dental procedures.
Schrag A, Bhatia KP, Quinn NP, Marsden CD. Schrag A, et al. Mov Disord. 1999 May;14(3):492-6. doi: 10.1002/1531-8257(199905)14:3<492::aid-mds1018>3.0.co;2-4. Mov Disord. 1999. PMID: 10348476
We report eight cases who developed cranial dystonia within hours to months following a dental procedure. One group of five cases, all women, developed atypical dystonia associated with painful paresthesias at the site of dystonia. ...The close association in time and loca …
We report eight cases who developed cranial dystonia within hours to months following a dental procedure. One group of five cases, al …
Sequential bilateral transplantation in Parkinson's disease: effects of the second graft.
Hagell P, Schrag A, Piccini P, Jahanshahi M, Brown R, Rehncrona S, Widner H, Brundin P, Rothwell JC, Odin P, Wenning GK, Morrish P, Gustavii B, Björklund A, Brooks DJ, Marsden CD, Quinn NP, Lindvall O. Hagell P, et al. Brain. 1999 Jun;122 ( Pt 6):1121-32. doi: 10.1093/brain/122.6.1121. Brain. 1999. PMID: 10356064
After 12-18 months, PET showed a mean 85% increase in 6-L-[18F]fluorodopa uptake in the putamen with the second graft, whereas there was no significant further change in the previously transplanted putamen. ...
After 12-18 months, PET showed a mean 85% increase in 6-L-[18F]fluorodopa uptake in the putamen with the second graft, whereas there …
Disorders of the basal ganglia and their modern management.
Schrag A, Quinn N. Schrag A, et al. J R Coll Physicians Lond. 1999 Jul-Aug;33(4):323-7. J R Coll Physicians Lond. 1999. PMID: 10472019 Review. No abstract available.
Differentiation of atypical parkinsonian syndromes with routine MRI.
Schrag A, Good CD, Miszkiel K, Morris HR, Mathias CJ, Lees AJ, Quinn NP. Schrag A, et al. Neurology. 2000 Feb 8;54(3):697-702. doi: 10.1212/wnl.54.3.697. Neurology. 2000. PMID: 10680806
However, in a minority of patients no unequivocal diagnosis can be made using MRI findings alone....
However, in a minority of patients no unequivocal diagnosis can be made using MRI findings alone....
Benign hereditary chorea--entity or syndrome?
Schrag A, Quinn NP, Bhatia KP, Marsden CD. Schrag A, et al. Mov Disord. 2000 Mar;15(2):280-8. doi: 10.1002/1531-8257(200003)15:2<280::aid-mds1011>3.0.co;2-q. Mov Disord. 2000. PMID: 10752577
In addition, we reviewed all patients in whom at least one of the authors had at some stage considered a possible diagnosis of BHC. ...We conclude that BHC is not a diagnosis, but a syndrome that requires further investigation. Whether there is a disti …
In addition, we reviewed all patients in whom at least one of the authors had at some stage considered a possible diagnosis of BHC. . …
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