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Innate and adaptive immune cells in the tumor microenvironment.
Gajewski TF, Schreiber H, Fu YX. Gajewski TF, et al. Among authors: schreiber h. Nat Immunol. 2013 Oct;14(10):1014-22. doi: 10.1038/ni.2703. Nat Immunol. 2013. PMID: 24048123 Free PMC article. Review.
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens T, Friese C, Arina A, Idel C, Briesemeister D, Rothe M, Ivanov A, Szymborska A, Patone G, Kunz S, Sommermeyer D, Engels B, Leisegang M, Textor A, Fehling HJ, Fruttiger M, Lohoff M, Herrmann A, Yu H, Weichselbaum R, Uckert W, Hübner N, Gerhardt H, Beule D, Schreiber H, Blankenstein T. Kammertoens T, et al. Among authors: schreiber h. Nature. 2017 May 4;545(7652):98-102. doi: 10.1038/nature22311. Epub 2017 Apr 26. Nature. 2017. PMID: 28445461 Free PMC article.
A strategy for generating cancer-specific monoclonal antibodies to aberrant O-glycoproteins: identification of a novel dysadherin-Tn antibody.
Steentoft C, Fuhrmann M, Battisti F, Van Coillie J, Madsen TD, Campos D, Halim A, Vakhrushev SY, Joshi HJ, Schreiber H, Mandel U, Narimatsu Y. Steentoft C, et al. Among authors: schreiber h. Glycobiology. 2019 Apr 1;29(4):307-319. doi: 10.1093/glycob/cwz004. Glycobiology. 2019. PMID: 30726901 Free PMC article.
IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner.
Liu RB, Engels B, Schreiber K, Ciszewski C, Schietinger A, Schreiber H, Jabri B. Liu RB, et al. Among authors: schreiber k, schreiber h. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8158-63. doi: 10.1073/pnas.1301022110. Epub 2013 May 1. Proc Natl Acad Sci U S A. 2013. PMID: 23637340 Free PMC article.
Tumor-specific immune responses.
Schreiber H. Schreiber H. Semin Immunol. 2008 Oct;20(5):265-6. doi: 10.1016/j.smim.2008.10.001. Epub 2008 Nov 1. Semin Immunol. 2008. PMID: 18977672 Free PMC article. No abstract available.
Recurrence of intracranial tumors following adoptive T cell therapy can be prevented by direct and indirect killing aided by high levels of tumor antigen cross-presented on stromal cells.
Thomas DL, Kim M, Bowerman NA, Narayanan S, Kranz DM, Schreiber H, Roy EJ. Thomas DL, et al. Among authors: schreiber h. J Immunol. 2009 Aug 1;183(3):1828-37. doi: 10.4049/jimmunol.0802322. Epub 2009 Jul 10. J Immunol. 2009. PMID: 19592642
To further test the role of cross-presentation, RAG1(-/-) H-2(b) mice were infused with H-2(k) tumor cells expressing high levels of SIY peptide. Adoptively transferred 2C T cells are able to kill cross-presenting H-2(b) stromal cells but not H-2(k) tu …
To further test the role of cross-presentation, RAG1(-/-) H-2(b) mice were infused with H-2(k) tumor cells expressing high lev …
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR.
Soto CM, Stone JD, Chervin AS, Engels B, Schreiber H, Roy EJ, Kranz DM. Soto CM, et al. Among authors: schreiber h. Cancer Immunol Immunother. 2013 Feb;62(2):359-69. doi: 10.1007/s00262-012-1336-z. Epub 2012 Aug 25. Cancer Immunol Immunother. 2013. PMID: 22926060 Free PMC article.
Equilibrium between host and cancer caused by effector T cells killing tumor stroma.
Zhang B, Zhang Y, Bowerman NA, Schietinger A, Fu YX, Kranz DM, Rowley DA, Schreiber H. Zhang B, et al. Among authors: schreiber h. Cancer Res. 2008 Mar 1;68(5):1563-71. doi: 10.1158/0008-5472.CAN-07-5324. Cancer Res. 2008. PMID: 18316622
Ribosomal versus non-ribosomal cellular antigens: factors determining efficiency of indirect presentation to CD4+ T cells.
Philip M, Schietinger A, Schreiber H. Philip M, et al. Among authors: schreiber h. Immunology. 2010 Aug;130(4):494-503. doi: 10.1111/j.1365-2567.2010.03258.x. Epub 2010 Mar 16. Immunology. 2010. PMID: 20331471 Free PMC article.
Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity.
Engels B, Chervin AS, Sant AJ, Kranz DM, Schreiber H. Engels B, et al. Among authors: schreiber h. Mol Ther. 2012 Mar;20(3):652-60. doi: 10.1038/mt.2011.286. Epub 2012 Jan 10. Mol Ther. 2012. PMID: 22233579 Free PMC article.
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