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Page 1
When lamins go bad: nuclear structure and disease.
Schreiber KH, Kennedy BK. Schreiber KH, et al. Cell. 2013 Mar 14;152(6):1365-75. doi: 10.1016/j.cell.2013.02.015. Cell. 2013. PMID: 23498943 Free PMC article. Review.
mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.
Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H. Haller S, et al. Among authors: schreiber kh. Cell Stem Cell. 2017 Dec 7;21(6):806-818.e5. doi: 10.1016/j.stem.2017.11.008. Cell Stem Cell. 2017. PMID: 29220665 Free PMC article.
The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.
O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, Academia EC, Shah SR, Morton JF, Holstein CA, Martin DB, Kaeberlein M, Ladiges WC, Fink PJ, Mackay VL, Wiest DL, Kennedy BK. O'Leary MN, et al. Among authors: schreiber kh. PLoS Genet. 2013;9(8):e1003708. doi: 10.1371/journal.pgen.1003708. Epub 2013 Aug 22. PLoS Genet. 2013. PMID: 23990801 Free PMC article.
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.
Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK. Ramos FJ, et al. Among authors: schreiber kh. Sci Transl Med. 2012 Jul 25;4(144):144ra103. doi: 10.1126/scitranslmed.3003802. Sci Transl Med. 2012. PMID: 22837538 Free PMC article.
A novel rapamycin analog is highly selective for mTORC1 in vivo.
Schreiber KH, Arriola Apelo SI, Yu D, Brinkman JA, Velarde MC, Syed FA, Liao CY, Baar EL, Carbajal KA, Sherman DS, Ortiz D, Brunauer R, Yang SE, Tzannis ST, Kennedy BK, Lamming DW. Schreiber KH, et al. Nat Commun. 2019 Jul 19;10(1):3194. doi: 10.1038/s41467-019-11174-0. Nat Commun. 2019. PMID: 31324799 Free PMC article.