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Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Whitesell L, Sutphin P, An WG, Schulte T, Blagosklonny MV, Neckers L. Whitesell L, et al. Among authors: schulte t. Oncogene. 1997 Jun 12;14(23):2809-16. doi: 10.1038/sj.onc.1201120. Oncogene. 1997. PMID: 9190897
Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex.
Shiotsu Y, Neckers LM, Wortman I, An WG, Schulte TW, Soga S, Murakata C, Tamaoki T, Akinaga S. Shiotsu Y, et al. Among authors: schulte tw. Blood. 2000 Sep 15;96(6):2284-91. Blood. 2000. PMID: 10979978
The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome.
An WG, Schulte TW, Neckers LM. An WG, et al. Among authors: schulte tw. Cell Growth Differ. 2000 Jul;11(7):355-60. Cell Growth Differ. 2000. PMID: 10939589 Free article.
KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.
Soga S, Neckers LM, Schulte TW, Shiotsu Y, Akasaka K, Narumi H, Agatsuma T, Ikuina Y, Murakata C, Tamaoki T, Akinaga S. Soga S, et al. Among authors: schulte tw. Cancer Res. 1999 Jun 15;59(12):2931-8. Cancer Res. 1999. PMID: 10383157 Free article.
The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation.
Grenert JP, Sullivan WP, Fadden P, Haystead TA, Clark J, Mimnaugh E, Krutzsch H, Ochel HJ, Schulte TW, Sausville E, Neckers LM, Toft DO. Grenert JP, et al. Among authors: schulte tw. J Biol Chem. 1997 Sep 19;272(38):23843-50. doi: 10.1074/jbc.272.38.23843. J Biol Chem. 1997. PMID: 9295332
Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.
Schulte TW, Akinaga S, Soga S, Sullivan W, Stensgard B, Toft D, Neckers LM. Schulte TW, et al. Cell Stress Chaperones. 1998 Jun;3(2):100-8. doi: 10.1379/1466-1268(1998)003<0100:arbttn>;2. Cell Stress Chaperones. 1998. PMID: 9672245 Free PMC article.
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.
Schulte TW, Akinaga S, Murakata T, Agatsuma T, Sugimoto S, Nakano H, Lee YS, Simen BB, Argon Y, Felts S, Toft DO, Neckers LM, Sharma SV. Schulte TW, et al. Mol Endocrinol. 1999 Sep;13(9):1435-48. doi: 10.1210/mend.13.9.0339. Mol Endocrinol. 1999. PMID: 10478836
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