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Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.
Drießen S, Berleth N, Friesen O, Löffler AS, Böhler P, Hieke N, Stuhldreier F, Peter C, Schink KO, Schultz SW, Stenmark H, Holland P, Simonsen A, Wesselborg S, Stork B. Drießen S, et al. Among authors: schultz sw. Autophagy. 2015;11(9):1458-70. doi: 10.1080/15548627.2015.1067359. Autophagy. 2015. PMID: 26207339 Free PMC article.
Microenvironmental autophagy promotes tumour growth.
Katheder NS, Khezri R, O'Farrell F, Schultz SW, Jain A, Rahman MM, Schink KO, Theodossiou TA, Johansen T, Juhász G, Bilder D, Brech A, Stenmark H, Rusten TE. Katheder NS, et al. Among authors: schultz sw. Nature. 2017 Jan 19;541(7637):417-420. doi: 10.1038/nature20815. Epub 2017 Jan 11. Nature. 2017. PMID: 28077876 Free PMC article.
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation.
Vietri M, Schultz SW, Bellanger A, Jones CM, Petersen LI, Raiborg C, Skarpen E, Pedurupillay CRJ, Kjos I, Kip E, Timmer R, Jain A, Collas P, Knorr RL, Grellscheid SN, Kusumaatmaja H, Brech A, Micci F, Stenmark H, Campsteijn C. Vietri M, et al. Among authors: schultz sw. Nat Cell Biol. 2020 Jul;22(7):856-867. doi: 10.1038/s41556-020-0537-5. Epub 2020 Jun 29. Nat Cell Biol. 2020. PMID: 32601372
27 results