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Cysteine-to-serine mutants dramatically reorder the active site of human ABO(H) blood group B glycosyltransferase without affecting activity: structural insights into cooperative substrate binding.
Schuman B, Persson M, Landry RC, Polakowski R, Weadge JT, Seto NO, Borisova SN, Palcic MM, Evans SV. Schuman B, et al. J Mol Biol. 2010 Sep 17;402(2):399-411. doi: 10.1016/j.jmb.2010.07.036. Epub 2010 Jul 23. J Mol Biol. 2010. PMID: 20655926 Free PMC article.
High-resolution crystal structures and STD NMR mapping of human ABO(H) blood group glycosyltransferases in complex with trisaccharide reaction products suggest a molecular basis for product release.
Gagnon SML, Legg MSG, Sindhuwinata N, Letts JA, Johal AR, Schuman B, Borisova SN, Palcic MM, Peters T, Evans SV. Gagnon SML, et al. Among authors: schuman b. Glycobiology. 2017 Oct 1;27(10):966-977. doi: 10.1093/glycob/cwx053. Glycobiology. 2017. PMID: 28575295
Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases.
Gagnon SML, Legg MSG, Polakowski R, Letts JA, Persson M, Lin S, Zheng RB, Rempel B, Schuman B, Haji-Ghassemi O, Borisova SN, Palcic MM, Evans SV. Gagnon SML, et al. Among authors: schuman b. Glycobiology. 2018 Aug 1;28(8):624-636. doi: 10.1093/glycob/cwy051. Glycobiology. 2018. PMID: 29873711 Free PMC article.
Using Smartphone Sensors for Ataxia Trials: Consensus Guidance by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers.
Németh AH, Antoniades CA, Dukart J, Minnerop M, Rentz C, Schuman BJ, van de Warrenburg B, Willemse I, Bertini E, Gupta AS, de Mello Monteiro CB, Almoajil H, Quinn L, Perlman SB, Horak F, Ilg W, Traschütz A, Vogel AP, Dawes H; AGI Digital-Motor Biomarkers Working Group. Németh AH, et al. Among authors: schuman bj. Cerebellum. 2023 Nov 28. doi: 10.1007/s12311-023-01608-3. Online ahead of print. Cerebellum. 2023. PMID: 38015365
131 results