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5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation.
Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Falck JR, Malik KU. Tunctan B, et al. Among authors: schunck wh. Prostaglandins Other Lipid Mediat. 2013 Apr-May;102-103:31-41. doi: 10.1016/j.prostaglandins.2013.01.005. Epub 2013 Feb 27. Prostaglandins Other Lipid Mediat. 2013. PMID: 23454652 Free PMC article.
Possible Role of CYP450 Generated Omega-3/Omega-6 PUFA Metabolites in the Modulation of Blood Pressure and Vascular Function in Obese Children.
Bonafini S, Giontella A, Tagetti A, Marcon D, Montagnana M, Benati M, Gaudino R, Cavarzere P, Karber M, Rothe M, Minuz P, Antonazzi F, Maffeis C, Schunck WH, Fava C. Bonafini S, et al. Among authors: schunck wh. Nutrients. 2018 Nov 5;10(11):1689. doi: 10.3390/nu10111689. Nutrients. 2018. PMID: 30400671 Free PMC article.
Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury.
Hoff U, Lukitsch I, Chaykovska L, Ladwig M, Arnold C, Manthati VL, Fuller TF, Schneider W, Gollasch M, Muller DN, Flemming B, Seeliger E, Luft FC, Falck JR, Dragun D, Schunck WH. Hoff U, et al. Among authors: schunck wh. Kidney Int. 2011 Jan;79(1):57-65. doi: 10.1038/ki.2010.377. Epub 2010 Oct 20. Kidney Int. 2011. PMID: 20962739 Free PMC article.
Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice.
Zhu Y, Blum M, Hoff U, Wesser T, Fechner M, Westphal C, Gürgen D, Catar RA, Philippe A, Wu K, Bubalo G, Rothe M, Weldon SM, Dragun D, Schunck WH. Zhu Y, et al. Among authors: schunck wh. PLoS One. 2016 Jan 4;11(1):e0145645. doi: 10.1371/journal.pone.0145645. eCollection 2016. PLoS One. 2016. PMID: 26727266 Free PMC article.
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