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Role of ion channels and transporters in cell migration.
Schwab A, Fabian A, Hanley PJ, Stock C. Schwab A, et al. Physiol Rev. 2012 Oct;92(4):1865-913. doi: 10.1152/physrev.00018.2011. Physiol Rev. 2012. PMID: 23073633 Review.
Cell motility is central to tissue homeostasis in health and disease, and there is hardly any cell in the body that is not motile at a given point in its life cycle. ...
Cell motility is central to tissue homeostasis in health and disease, and there is hardly any cell in the body that is not motile at a
TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration.
Nielsen N, Lindemann O, Schwab A. Nielsen N, et al. Among authors: schwab a. Br J Pharmacol. 2014 Dec;171(24):5524-40. doi: 10.1111/bph.12721. Epub 2014 Jul 2. Br J Pharmacol. 2014. PMID: 24724725 Free PMC article. Review.
This leads to the development of a tumour microenvironment with distinct physical and chemical properties that are permissive for tumour progression. The ability to migrate plays a central role in this mutual interaction. Migration of cancer cells is considered as …
This leads to the development of a tumour microenvironment with distinct physical and chemical properties that are permissive for tum …
Role of the Na/H exchanger NHE1 in cell migration.
Stock C, Schwab A. Stock C, et al. Among authors: schwab a. Acta Physiol (Oxf). 2006 May-Jun;187(1-2):149-57. doi: 10.1111/j.1748-1716.2006.01543.x. Acta Physiol (Oxf). 2006. PMID: 16734751 Review.
Cell migration plays a basic role in many physiological and pathophysiological processes such as embryogenesis, immune defence, wound healing or metastasis. ...The present article gives a review of the different ways in which NHE1 is involved in and contributes to c …
Cell migration plays a basic role in many physiological and pathophysiological processes such as embryogenesis, immune defence, wound …
TRPC1 channels regulate directionality of migrating cells.
Fabian A, Fortmann T, Dieterich P, Riethmüller C, Schön P, Mally S, Nilius B, Schwab A. Fabian A, et al. Among authors: schwab a. Pflugers Arch. 2008 Nov;457(2):475-84. doi: 10.1007/s00424-008-0515-4. Epub 2008 Apr 30. Pflugers Arch. 2008. PMID: 18542994
As shown by time lapse video microscopy, TRPC1 knockdown cells have partially lost their polarity and the ability to persistently migrate into a given direction. This failure is linked to the suppression of a local Ca(2+) gradient at the front of migrating TRPC1 kno …
As shown by time lapse video microscopy, TRPC1 knockdown cells have partially lost their polarity and the ability to persistently migrate in …
TRPC1 regulates fMLP-stimulated migration and chemotaxis of neutrophil granulocytes.
Lindemann O, Strodthoff C, Horstmann M, Nielsen N, Jung F, Schimmelpfennig S, Heitzmann M, Schwab A. Lindemann O, et al. Among authors: schwab a. Biochim Biophys Acta. 2015 Sep;1853(9):2122-30. doi: 10.1016/j.bbamcr.2014.12.037. Epub 2015 Jan 14. Biochim Biophys Acta. 2015. PMID: 25595528
We show that the enhanced Ca²⁺ influx in the TRPC1(-/-) neutrophils is associated with a steepened front to rear gradient of the intracellular Ca²⁺ concentration with higher levels at the cell rear. ...This article is part of a Special Issue entitled: 13th European …
We show that the enhanced Ca²⁺ influx in the TRPC1(-/-) neutrophils is associated with a steepened front to rear gradient of the intr …
The atomic force microscope detects ATP-sensitive protein clusters in the plasma membrane of transformed MDCK cells.
Ehrenhöfer U, Rakowska A, Schneider SW, Schwab A, Oberleithner H. Ehrenhöfer U, et al. Among authors: schwab a. Cell Biol Int. 1997 Nov;21(11):737-46. doi: 10.1006/cbir.1997.0218. Cell Biol Int. 1997. PMID: 9768472
Therefore, we developed a technique to get access to the inner face of the plasma membrane of cultured transformed kidney (MDCK) cells. ...The 'physiological' arrangement of the protein molecules within a cluster requires ATP....
Therefore, we developed a technique to get access to the inner face of the plasma membrane of cultured transformed kidney (MDCK) cell …
A novel function of capsaicin-sensitive TRPV1 channels: involvement in cell migration.
Waning J, Vriens J, Owsianik G, Stüwe L, Mally S, Fabian A, Frippiat C, Nilius B, Schwab A. Waning J, et al. Among authors: schwab a. Cell Calcium. 2007 Jul;42(1):17-25. doi: 10.1016/j.ceca.2006.11.005. Epub 2006 Dec 20. Cell Calcium. 2007. PMID: 17184838
Cell migration relies on a tight temporal and spatial regulation of the intracellular Ca2+ concentration ([Ca2+]i). [Ca2+]i in turn depends on Ca2+ influx via channels in the plasma membrane whose molecular nature is still largely unknown for migrating cells. ...A s …
Cell migration relies on a tight temporal and spatial regulation of the intracellular Ca2+ concentration ([Ca2+]i). [Ca2+]i in turn d …
Volume dynamics in migrating epithelial cells measured with atomic force microscopy.
Schneider SW, Pagel P, Rotsch C, Danker T, Oberleithner H, Radmacher M, Schwab A. Schneider SW, et al. Among authors: schwab a. Pflugers Arch. 2000 Jan;439(3):297-303. doi: 10.1007/s004249900176. Pflugers Arch. 2000. PMID: 10650981
Migration of transformed renal epithelial cells (transformed Madin-Darby canine kidney cells, MDCK-F cells) relies on the activity of a Ca(2+)-sensitive K+ channel (IK channel) that is more active at the rear end of these cells. ...The spatial (x, y' and z) co-ordinates of …
Migration of transformed renal epithelial cells (transformed Madin-Darby canine kidney cells, MDCK-F cells) relies on the activity of a
Functional role of Na+-HCO3- cotransport in migration of transformed renal epithelial cells.
Schwab A, Rossmann H, Klein M, Dieterich P, Gassner B, Neff C, Stock C, Seidler U. Schwab A, et al. J Physiol. 2005 Oct 15;568(Pt 2):445-58. doi: 10.1113/jphysiol.2005.092957. Epub 2005 Jul 21. J Physiol. 2005. PMID: 16037087 Free PMC article.
We found that MDCK-F cells express the isoform NBC1 (SLCA4A gene product) at a much higher level than the isoform kNBC3 (SLCA4A8 gene product). ...NBC activity promotes migration during an acute intracellular acid load and increases migratory speed and displacement on a
We found that MDCK-F cells express the isoform NBC1 (SLCA4A gene product) at a much higher level than the isoform kNBC3 (SLCA4A8 gene …
Polarization of Na(+)/H(+) and Cl(-)/HCO (3)(-) exchangers in migrating renal epithelial cells.
Klein M, Seeger P, Schuricht B, Alper SL, Schwab A. Klein M, et al. Among authors: schwab a. J Gen Physiol. 2000 May;115(5):599-608. doi: 10.1085/jgp.115.5.599. J Gen Physiol. 2000. PMID: 10779317 Free PMC article.
Both transporters are required for locomotion of renal epithelial (Madin-Darby canine kidney, MDCK-F) cells and human melanoma cells since their blockade reduces the rate of migration in a dose-dependent manner. Inhibition of migration of MDCK-F cells by NHE blockers is ac …
Both transporters are required for locomotion of renal epithelial (Madin-Darby canine kidney, MDCK-F) cells and human melanoma cells since t …
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