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Astrocytes are GABAergic cells that modulate microglial activity.
Lee M, Schwab C, McGeer PL. Lee M, et al. Glia. 2011 Jan;59(1):152-65. doi: 10.1002/glia.21087. Glia. 2011. PMID: 21046567
Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide.
Lee M, Schwab C, Yu S, McGeer E, McGeer PL. Lee M, et al. Neurobiol Aging. 2009 Oct;30(10):1523-34. doi: 10.1016/j.neurobiolaging.2009.06.001. Epub 2009 Jul 23. Neurobiol Aging. 2009. PMID: 19631409
Interferon-gamma-dependent cytotoxic activation of human astrocytes and astrocytoma cells.
Hashioka S, Klegeris A, Schwab C, McGeer PL. Hashioka S, et al. Neurobiol Aging. 2009 Dec;30(12):1924-35. doi: 10.1016/j.neurobiolaging.2008.02.019. Epub 2008 Mar 28. Neurobiol Aging. 2009. PMID: 18375019
Acidic fibroblast growth factor (FGF) potentiates glial-mediated neurotoxicity by activating FGFR2 IIIb protein.
Lee M, Kang Y, Suk K, Schwab C, Yu S, McGeer PL. Lee M, et al. J Biol Chem. 2011 Dec 2;286(48):41230-45. doi: 10.1074/jbc.M111.270470. Epub 2011 Oct 11. J Biol Chem. 2011. PMID: 21990352 Free PMC article.
The inflammatory effect was also attenuated by treatment with inhibitors of protein kinase C, Src tyrosine kinase, and MEK-1/2 indicating the involvement of these intracellular pathways. ...
The inflammatory effect was also attenuated by treatment with inhibitors of protein kinase C, Src tyrosine kinase, and MEK-1/2 indica …
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