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FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P(3) and phosphoinositide 3-kinase.
Imeri F, Blanchard O, Jenni A, Schwalm S, Wünsche C, Zivkovic A, Stark H, Pfeilschifter J, Huwiler A. Imeri F, et al. Among authors: schwalm s. Naunyn Schmiedebergs Arch Pharmacol. 2015 Dec;388(12):1283-92. doi: 10.1007/s00210-015-1159-5. Epub 2015 Aug 13. Naunyn Schmiedebergs Arch Pharmacol. 2015. PMID: 26267293
Transforming growth factor β2 (TGF-β2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells.
Wünsche C, Koch A, Goldschmeding R, Schwalm S, Meyer Zu Heringdorf D, Huwiler A, Pfeilschifter J. Wünsche C, et al. Among authors: schwalm s. Biochim Biophys Acta. 2015 May;1851(5):519-26. doi: 10.1016/j.bbalip.2015.01.003. Epub 2015 Jan 17. Biochim Biophys Acta. 2015. PMID: 25601519
Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice.
Imeri F, Fallegger D, Zivkovic A, Schwalm S, Enzmann G, Blankenbach K, Meyer zu Heringdorf D, Homann T, Kleuser B, Pfeilschifter J, Engelhardt B, Stark H, Huwiler A. Imeri F, et al. Among authors: schwalm s. Neuropharmacology. 2014 Oct;85:314-27. doi: 10.1016/j.neuropharm.2014.05.012. Epub 2014 May 23. Neuropharmacology. 2014. PMID: 24863045
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