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Schwann cells express motor and sensory phenotypes that regulate axon regeneration.
Höke A, Redett R, Hameed H, Jari R, Zhou C, Li ZB, Griffin JW, Brushart TM. Höke A, et al. J Neurosci. 2006 Sep 20;26(38):9646-55. doi: 10.1523/JNEUROSCI.1620-06.2006. J Neurosci. 2006. PMID: 16988035 Free PMC article.
To explore potential differences in growth factor expression between sensory and motor nerve, grafts of cutaneous nerve or ventral root were denervated, reinnervated with cutaneous axons, or reinnervated with motor axons. ...Schwann
To explore potential differences in growth factor expression between sensory and motor nerve, grafts of cutaneous nerve …
Novel roles for osteopontin and clusterin in peripheral motor and sensory axon regeneration.
Wright MC, Mi R, Connor E, Reed N, Vyas A, Alspalter M, Coppola G, Geschwind DH, Brushart TM, Höke A. Wright MC, et al. J Neurosci. 2014 Jan 29;34(5):1689-700. doi: 10.1523/JNEUROSCI.3822-13.2014. J Neurosci. 2014. PMID: 24478351 Free PMC article.
Previous studies demonstrated that Schwann cells (SCs) express distinct motor and sensory phenotypes, which impact the ability of these pathways to selectively support regenerating neurons. ...Together, these studies suggest unique …
Previous studies demonstrated that Schwann cells (SCs) express distinct motor and sensory phenotypes
Glial cell line-derived neurotrophic factor promotes increased phenotypic marker expression in femoral sensory and motor-derived Schwann cell cultures.
Jesuraj NJ, Marquardt LM, Kwasa JA, Sakiyama-Elbert SE. Jesuraj NJ, et al. Exp Neurol. 2014 Jul;257:10-8. doi: 10.1016/j.expneurol.2014.04.005. Epub 2014 Apr 13. Exp Neurol. 2014. PMID: 24731946 Free PMC article.
Schwann cells (SCs) secrete growth factors and extracellular matrix molecules that promote neuronal survival and help guide axons during regeneration. ...The exogenous GDNF promoted differentiation of sensory and motor-derived SCs back to
Schwann cells (SCs) secrete growth factors and extracellular matrix molecules that promote neuronal survival and help guide
Modification of Schwann cell gene expression by electroporation in vivo.
Aspalter M, Vyas A, Feiner J, Griffin J, Brushart T, Redett R. Aspalter M, et al. J Neurosci Methods. 2009 Jan 30;176(2):96-103. doi: 10.1016/j.jneumeth.2008.08.035. Epub 2008 Sep 11. J Neurosci Methods. 2009. PMID: 18834904 Free PMC article.
This may be due, in part, to the routine use of cutaneous nerve to support motor axon regeneration. In previous work, we have demonstrated that Schwann cells express distinct sensory and motor phenotypes, and that the …
This may be due, in part, to the routine use of cutaneous nerve to support motor axon regeneration. In previous work, w …
Insights Into the Role and Potential of Schwann Cells for Peripheral Nerve Repair From Studies of Development and Injury.
Balakrishnan A, Belfiore L, Chu TH, Fleming T, Midha R, Biernaskie J, Schuurmans C. Balakrishnan A, et al. Front Mol Neurosci. 2021 Jan 25;13:608442. doi: 10.3389/fnmol.2020.608442. eCollection 2020. Front Mol Neurosci. 2021. PMID: 33568974 Free PMC article.
Schwann cells are required for successful nerve regeneration; they partially "de-differentiate" in response to injury, re-initiating the expression of developmental genes that support nerve repair. ...Cell replacement-based therapeutic approaches using
Schwann cells are required for successful nerve regeneration; they partially "de-differentiate" in response to injury,
Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy.
Chumakov I, Milet A, Cholet N, Primas G, Boucard A, Pereira Y, Graudens E, Mandel J, Laffaire J, Foucquier J, Glibert F, Bertrand V, Nave KA, Sereda MW, Vial E, Guedj M, Hajj R, Nabirotchkin S, Cohen D. Chumakov I, et al. Orphanet J Rare Dis. 2014 Dec 10;9:201. doi: 10.1186/s13023-014-0201-x. Orphanet J Rare Dis. 2014. PMID: 25491744 Free PMC article.
Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited sensory and motor peripheral neuropathy. It is caused by PMP22 overexpression which leads to defects of peripheral myelination, loss of long axons, and progressive impairment then disabi …
Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited sensory and motor peripheral neuropathy. It is caused …