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Structural biology: Full monty of family B GPCRs.
Schwartz TW, Frimurer TM. Schwartz TW, et al. Nat Chem Biol. 2017 Jul 18;13(8):819-821. doi: 10.1038/nchembio.2438. Nat Chem Biol. 2017. PMID: 28853739 No abstract available.
Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1.
Lückmann M, Trauelsen M, Bentsen MA, Nissen TAD, Martins J, Fallah Z, Nygaard MM, Papaleo E, Lindorff-Larsen K, Schwartz TW, Frimurer TM. Lückmann M, et al. Among authors: schwartz tw. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7123-7128. doi: 10.1073/pnas.1811066116. Epub 2019 Mar 14. Proc Natl Acad Sci U S A. 2019. PMID: 30872479 Free PMC article.
GPCR-Mediated Signaling of Metabolites.
Husted AS, Trauelsen M, Rudenko O, Hjorth SA, Schwartz TW. Husted AS, et al. Among authors: schwartz tw. Cell Metab. 2017 Apr 4;25(4):777-796. doi: 10.1016/j.cmet.2017.03.008. Cell Metab. 2017. PMID: 28380372 Review.
GPR119 as a fat sensor.
Hansen HS, Rosenkilde MM, Holst JJ, Schwartz TW. Hansen HS, et al. Among authors: schwartz tw. Trends Pharmacol Sci. 2012 Jul;33(7):374-81. doi: 10.1016/j.tips.2012.03.014. Epub 2012 May 2. Trends Pharmacol Sci. 2012. PMID: 22560300 Review.
The minor binding pocket: a major player in 7TM receptor activation.
Rosenkilde MM, Benned-Jensen T, Frimurer TM, Schwartz TW. Rosenkilde MM, et al. Among authors: schwartz tw. Trends Pharmacol Sci. 2010 Dec;31(12):567-74. doi: 10.1016/j.tips.2010.08.006. Epub 2010 Sep 25. Trends Pharmacol Sci. 2010. PMID: 20870300
GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.
Nøhr MK, Pedersen MH, Gille A, Egerod KL, Engelstoft MS, Husted AS, Sichlau RM, Grunddal KV, Poulsen SS, Han S, Jones RM, Offermanns S, Schwartz TW. Nøhr MK, et al. Among authors: schwartz tw. Endocrinology. 2013 Oct;154(10):3552-64. doi: 10.1210/en.2013-1142. Epub 2013 Jul 24. Endocrinology. 2013. PMID: 23885020
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