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Increased urinary excretion of 8-iso-prostaglandin F2alpha in patients with HFE-related hemochromatosis: a case-control study.
Kom GD, Schwedhelm E, Nielsen P, Böger RH. Kom GD, et al. Among authors: schwedhelm e. Free Radic Biol Med. 2006 Apr 1;40(7):1194-200. doi: 10.1016/j.freeradbiomed.2005.11.004. Epub 2005 Dec 13. Free Radic Biol Med. 2006. PMID: 16545687
Study parameters were transferrin saturation, 8-iso-PGF(2alpha) urine excretion, transferrin, ferritin, serum iron, and vitamins A and E for all participants. ...Vitamin A was significantly reduced in cases (0.34 [0.25-1.83] microg/ml compared to 3.00 [2.11-3.39] microg/ml …
Study parameters were transferrin saturation, 8-iso-PGF(2alpha) urine excretion, transferrin, ferritin, serum iron, and vitamins A and E
Specific and rapid quantification of 8-iso-prostaglandin F2alpha in urine of healthy humans and patients with Zellweger syndrome by gas chromatography-tandem mass spectrometry.
Tsikas D, Schwedhelm E, Fauler J, Gutzki FM, Mayatepek E, Frölich JC. Tsikas D, et al. Among authors: schwedhelm e. J Chromatogr B Biomed Sci Appl. 1998 Sep 25;716(1-2):7-17. doi: 10.1016/s0378-4347(98)00275-8. J Chromatogr B Biomed Sci Appl. 1998. PMID: 9824213
We measured highly elevated excretion of 8-iso-PGF2alpha in the urine of children with peroxisomal beta-oxidation deficiency, i.e. ...
We measured highly elevated excretion of 8-iso-PGF2alpha in the urine of children with peroxisomal beta-oxidation deficiency, i.e. .. …
Dietary L-arginine and alpha-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms.
Böger RH, Bode-Böger SM, Phivthong-ngam L, Brandes RP, Schwedhelm E, Mügge A, Böhme M, Tsikas D, Frölich JC. Böger RH, et al. Among authors: schwedhelm e. Atherosclerosis. 1998 Nov;141(1):31-43. doi: 10.1016/s0021-9150(98)00145-2. Atherosclerosis. 1998. PMID: 9863536
L-Arginine increased urinary nitrate excretion by 43+/-13% (P <0.05) and reduced superoxide radical release by isolated aortic rings to control levels, which was unaffected by vitamin E treatment. By contrast, vitamin E dramatically increased the resistance of is …
L-Arginine increased urinary nitrate excretion by 43+/-13% (P <0.05) and reduced superoxide radical release by isolated aortic rings to c …
Gas chromatographic-tandem mass spectrometric quantification of free 3-nitrotyrosine in human plasma at the basal state.
Schwedhelm E, Tsikas D, Gutzki FM, Frölich JC. Schwedhelm E, et al. Anal Biochem. 1999 Dec 15;276(2):195-203. doi: 10.1006/abio.1999.4361. Anal Biochem. 1999. PMID: 10603243
Tandem mass spectrometric quantification of 8-iso-prostaglandin F2alpha and its metabolite 2,3-dinor-5,6-dihydro-8-iso-prostaglandin F2alpha in human urine.
Schwedhelm E, Tsikas D, Durand T, Gutzki FM, Guy A, Rossi JC, Frölich JC. Schwedhelm E, et al. J Chromatogr B Biomed Sci Appl. 2000 Jul 7;744(1):99-112. doi: 10.1016/s0378-4347(00)00236-x. J Chromatogr B Biomed Sci Appl. 2000. PMID: 10985571
Nebivolol decreases systemic oxidative stress in healthy volunteers.
Troost R, Schwedhelm E, Rojczyk S, Tsikas D, Frölich JC. Troost R, et al. Among authors: schwedhelm e. Br J Clin Pharmacol. 2000 Oct;50(4):377-9. doi: 10.1046/j.1365-2125.2000.00258.x. Br J Clin Pharmacol. 2000. PMID: 11012562 Free PMC article. Clinical Trial.
RESULTS: After the 7 day treatment period nebivolol decreased significantly urinary excretion of 8-iso-PGF2alpha by 24% from 55.3 +/- 5.1 pmol mmol-1 creatinine during the placebo period to 42.3 +/- 4.7 pmol mmol-1 creatinine (mean +/- s.e. mean, P = 0. 01), a mean decreas …
RESULTS: After the 7 day treatment period nebivolol decreased significantly urinary excretion of 8-iso-PGF2alpha by 24% from 55.3 +/- 5.1 pm …
ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins.
Sydow K, Schwedhelm E, Arakawa N, Bode-Böger SM, Tsikas D, Hornig B, Frölich JC, Böger RH. Sydow K, et al. Among authors: schwedhelm e. Cardiovasc Res. 2003 Jan;57(1):244-52. doi: 10.1016/s0008-6363(02)00617-x. Cardiovasc Res. 2003. PMID: 12504835 Clinical Trial.
OBJECTIVES: Hyperhomocyst(e)inemia is a risk factor for atherosclerotic vascular disease, and it is associated with endothelial dysfunction. ...These findings may have importance for evaluation of homocyst(e)ine-lowering therapy....
OBJECTIVES: Hyperhomocyst(e)inemia is a risk factor for atherosclerotic vascular disease, and it is associated with endothelial dysfu …
Divergence in urinary 8-iso-PGF(2alpha) (iPF(2alpha)-III, 15-F(2t)-IsoP) levels from gas chromatography-tandem mass spectrometry quantification after thin-layer chromatography and immunoaffinity column chromatography reveals heterogeneity of 8-iso-PGF(2alpha). Possible methodological, mechanistic and clinical implications.
Tsikas D, Schwedhelm E, Suchy MT, Niemann J, Gutzki FM, Erpenbeck VJ, Hohlfeld JM, Surdacki A, Frölich JC. Tsikas D, et al. Among authors: schwedhelm e. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Sep 5;794(2):237-55. doi: 10.1016/s1570-0232(03)00457-4. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 12954376
Immunoaffinity column chromatography (IAC) with immobilized antibodies raised against 8-iso-PGF(2alpha) (i.e. 15(S)-8-iso-PGF(2alpha)) has been shown by others to be highly selective and specific for this 8-iso-PGF(2alpha) isomer when quantified by GC-MS. ...Analysis of th …
Immunoaffinity column chromatography (IAC) with immobilized antibodies raised against 8-iso-PGF(2alpha) (i.e. 15(S)-8-iso-PGF(2alpha) …
Application of gas chromatography-mass spectrometry for analysis of isoprostanes: their role in cardiovascular disease.
Schwedhelm E, Böger RH. Schwedhelm E, et al. Clin Chem Lab Med. 2003 Dec;41(12):1552-61. doi: 10.1515/CCLM.2003.238. Clin Chem Lab Med. 2003. PMID: 14708879 Review.
The isoprostanes are derivatives of one specific lipid, i.e., arachidonic acid, after lipid peroxidation. Several isoprostanes have been identified in biological tissues and fluids, among them 8-iso prostaglandin F2alpha (8-iso-PGF2alpha, 8-epi-PGF2alpha, iPF2alpha-III, 15 …
The isoprostanes are derivatives of one specific lipid, i.e., arachidonic acid, after lipid peroxidation. Several isoprostanes have b …
Urinary 8-iso-prostaglandin F2alpha as a risk marker in patients with coronary heart disease: a matched case-control study.
Schwedhelm E, Bartling A, Lenzen H, Tsikas D, Maas R, Brümmer J, Gutzki FM, Berger J, Frölich JC, Böger RH. Schwedhelm E, et al. Circulation. 2004 Feb 24;109(7):843-8. doi: 10.1161/01.CIR.0000116761.93647.30. Epub 2004 Feb 2. Circulation. 2004. PMID: 14757688
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