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Did you mean m schwedhelm citrulline arginine (2 results)?
Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.
Schwedhelm E, Maas R, Freese R, Jung D, Lukacs Z, Jambrecina A, Spickler W, Schulze F, Böger RH. Schwedhelm E, et al. Br J Clin Pharmacol. 2008 Jan;65(1):51-9. doi: 10.1111/j.1365-2125.2007.02990.x. Epub 2007 Jul 27. Br J Clin Pharmacol. 2008. PMID: 17662090 Free PMC article. Clinical Trial.

RESULTS: L-Citrulline dose-dependently increased AUC and C(max) of plasma L-arginine concentration more effectively than L-arginine (P < 0.01). The highest dose of citrulline (3 g bid) increased the C(min) of plasma L-arginine and improved th

…
RESULTS: L-Citrulline dose-dependently increased AUC and C(max) of plasma L-arginine concentration more effectively than L- …
Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage.
Mader MM, Böger R, Appel D, Schwedhelm E, Haddad M, Mohme M, Lamszus K, Westphal M, Czorlich P, Hannemann J. Mader MM, et al. J Cereb Blood Flow Metab. 2021 Aug;41(8):1964-1977. doi: 10.1177/0271678X20983216. Epub 2021 Jan 18. J Cereb Blood Flow Metab. 2021. PMID: 33461409 Free PMC article.
Alterations in the concentration of nitric oxide (NO) and L-arginine metabolites have been associated with the pathophysiology of different vascular diseases. ...For arginase, a pattern of persistently elevated activity was measured and arginine:glycine amidinotrans …
Alterations in the concentration of nitric oxide (NO) and L-arginine metabolites have been associated with the pathophysiology of dif …
Biomarkers of the L-Arginine/Dimethylarginine/Nitric Oxide Pathway in People with Chronic Airflow Obstruction and Obstructive Sleep Apnoea.
Hannemann J, Thorarinnsdottir EH, Amaral AFS, Schwedhelm E, Schmidt-Hutten L, Stang H, Benediktsdottir B, Gunnarsdóttir I, Gislason T, Böger R. Hannemann J, et al. J Clin Med. 2023 Aug 11;12(16):5230. doi: 10.3390/jcm12165230. J Clin Med. 2023. PMID: 37629272 Free PMC article.
Patients affected by the overlap of COPD and OSA have a particularly unfavourable prognosis. The L-arginine/nitric oxide (NO) pathway plays an important role in regulating pulmonary vascular function. ...METHODS: We analysed the serum concentrations of ADMA, SDMA, L-arg …
Patients affected by the overlap of COPD and OSA have a particularly unfavourable prognosis. The L-arginine/nitric oxide (NO) pathway …
Arginine metabolism and nitric oxide turnover in the ZSF1 animal model for heart failure with preserved ejection fraction.
Büttner P, Werner S, Baskal S, Tsikas D, Adams V, Lurz P, Besler C, Knauth S, Bahls M, Schwedhelm E, Thiele H. Büttner P, et al. Sci Rep. 2021 Oct 19;11(1):20684. doi: 10.1038/s41598-021-00216-7. Sci Rep. 2021. PMID: 34667218 Free PMC article.
Ornithine (+ 60%) and citrulline (+ 20%) levels were higher. Similar results were found in the heart. Expression of arginine consuming enzymes in liver and kidney was unchanged. ...We conclude that inflammatory cells in blood and heart consume arginine and pr …
Ornithine (+ 60%) and citrulline (+ 20%) levels were higher. Similar results were found in the heart. Expression of arginine c …
Association of proton pump inhibitor use with endothelial function and metabolites of the nitric oxide pathway: A cross-sectional study.
Nolde M, Bahls M, Friedrich N, Dörr M, Dreischulte T, Felix SB, Rückert-Eheberg IM, Ahn N, Amann U, Schwedhelm E, Völzke H, Lerch MM, Linseisen J, Meisinger C, Baumeister SE. Nolde M, et al. Pharmacotherapy. 2021 Feb;41(2):198-204. doi: 10.1002/phar.2504. Epub 2021 Feb 4. Pharmacotherapy. 2021. PMID: 33465818
We therefore focused on changes in plasma citrulline as an indicator for potential DDAH inhibition. DESIGN: We analyzed the association between regular daily PPI intake and flow-mediated dilation (FMD) of the brachial artery as well as plasma concentrations of citrullin …
We therefore focused on changes in plasma citrulline as an indicator for potential DDAH inhibition. DESIGN: We analyzed the associati …
Nitric oxide synthesis capacity, ambulatory blood pressure and end organ damage in a black and white population: the SABPA study.
Mels CMC, Loots I, Schwedhelm E, Atzler D, Böger RH, Schutte AE. Mels CMC, et al. Amino Acids. 2016 Mar;48(3):801-810. doi: 10.1007/s00726-015-2128-5. Epub 2015 Nov 16. Amino Acids. 2016. PMID: 26573539
We compared ambulatory blood pressure (BP), markers of end organ damage and NO synthesis capacity markers [L-arginine, L-homoarginine, L-citrulline, L-arginine:ADMA, ADMA, SDMA and dimethylarginine (DMA)], between black and white teachers (n = 390). ...Althou …
We compared ambulatory blood pressure (BP), markers of end organ damage and NO synthesis capacity markers [L-arginine, L-homoarginine …
Asymmetric and symmetric dimethylarginine in high altitude pulmonary hypertension (HAPH) and high altitude pulmonary edema (HAPE).
Hannemann J, Freytag J, Schiefer LM, Macholz F, Sareban M, Schmidt-Hutten L, Stang H, Schwedhelm E, Swenson ER, Böger R, Berger MM. Hannemann J, et al. Front Physiol. 2023 Nov 29;14:1297636. doi: 10.3389/fphys.2023.1297636. eCollection 2023. Front Physiol. 2023. PMID: 38093907 Free PMC article.
Methods: We studied the effect of acute high altitude exposure on the plasma concentrations of asymmetric (ADMA) and symmetric dimethylarginine (SDMA), L-arginine, L-ornithine, and L-citrulline in two independent studies. We further investigated whether these biomar …
Methods: We studied the effect of acute high altitude exposure on the plasma concentrations of asymmetric (ADMA) and symmetric dimethylargin …
Central systolic blood pressure relates inversely to nitric oxide synthesis in young black adults: the African-PREDICT study.
Craig A, M C Mels C, Tsikas D, Boeger RH, Schwedhelm E, Schutte AE, Kruger R. Craig A, et al. J Hum Hypertens. 2021 Nov;35(11):985-993. doi: 10.1038/s41371-020-00453-9. Epub 2020 Dec 3. J Hum Hypertens. 2021. PMID: 33273698
We included healthy black and white men and women (n = 1110; 20-30 years) and measured cSBP and pulse wave velocity (PWV), along with both plasma and urinary arginine, homoarginine, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), as well as urinary o …
We included healthy black and white men and women (n = 1110; 20-30 years) and measured cSBP and pulse wave velocity (PWV), along with both p …
A multicenter study of asymmetric and symmetric dimethylarginine as predictors of mortality risk in hospitalized COVID-19 patients.
Hannemann J, Zink A, Mileva Y, Balfanz P, Dahl E, Volland S, Illig T, Schwedhelm E, Kurth F, Stege A, Aepfelbacher M, Hoffmann A, Böger R. Hannemann J, et al. Sci Rep. 2024 Jul 8;14(1):15739. doi: 10.1038/s41598-024-66288-3. Sci Rep. 2024. PMID: 38977837 Free PMC article.
Symmetric (SDMA) and asymmetric dimethylarginine (ADMA) have been proposed as possible biomarkers to improve risk prediction of COVID-19 patients. We measured SDMA, ADMA, and other L-arginine-related metabolites in 180 patients admitted with COVID-19 in four German univers …
Symmetric (SDMA) and asymmetric dimethylarginine (ADMA) have been proposed as possible biomarkers to improve risk prediction of COVID-19 pat …
Increased Serum Levels of Asymmetric Dimethylarginine and Symmetric Dimethylarginine and Decreased Levels of Arginine in Sudanese Patients with Essential Hypertension.
Gamil S, Erdmann J, Schwedhelm E, Bakheit KH, Abdalrahman IBB, Mohamed AO. Gamil S, et al. Kidney Blood Press Res. 2020;45(5):727-736. doi: 10.1159/000508695. Epub 2020 Aug 19. Kidney Blood Press Res. 2020. PMID: 32814314 Free article.
It is produced in endothelial cells by endothelial NO synthase (eNOS) that mediates the conversion of the amino acid arginine into NO and citrulline. Asymmetric dimethylarginine (ADMA) acts as an inhibitor of eNOS. ...CONCLUSIONS: This study demonstrated increased s …
It is produced in endothelial cells by endothelial NO synthase (eNOS) that mediates the conversion of the amino acid arginine into NO …
14 results