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Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.
Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P. Prox J, et al. Among authors: schweizer m. J Neurosci. 2013 Aug 7;33(32):12915-28, 12928a. doi: 10.1523/JNEUROSCI.5910-12.2013. J Neurosci. 2013. PMID: 23926248 Free PMC article.
Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II.
Markmann S, Krambeck S, Hughes CJ, Mirzaian M, Aerts JM, Saftig P, Schweizer M, Vissers JP, Braulke T, Damme M. Markmann S, et al. Among authors: schweizer m. Mol Cell Proteomics. 2017 Mar;16(3):438-450. doi: 10.1074/mcp.M116.063636. Epub 2017 Jan 6. Mol Cell Proteomics. 2017. PMID: 28062798 Free PMC article.
Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes.
Gonzalez AC, Schweizer M, Jagdmann S, Bernreuther C, Reinheckel T, Saftig P, Damme M. Gonzalez AC, et al. Among authors: schweizer m. Cell Rep. 2018 Jan 23;22(4):1040-1053. doi: 10.1016/j.celrep.2017.12.100. Epub 2018 Jan 28. Cell Rep. 2018. PMID: 29386126 Free article.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.
Reinicke AT, Laban K, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch PC, Duncan KE, Saftig P, Rinschen MM, Morellini F, Meyer-Schwesinger C. Reinicke AT, et al. Among authors: schweizer m. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7963-7972. doi: 10.1073/pnas.1812413116. Epub 2019 Mar 28. Proc Natl Acad Sci U S A. 2019. PMID: 30923110 Free PMC article.
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance.
Rothaug M, Zunke F, Mazzulli JR, Schweizer M, Altmeppen H, Lüllmann-Rauch R, Kallemeijn WW, Gaspar P, Aerts JM, Glatzel M, Saftig P, Krainc D, Schwake M, Blanz J. Rothaug M, et al. Among authors: schweizer m. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15573-8. doi: 10.1073/pnas.1405700111. Epub 2014 Oct 14. Proc Natl Acad Sci U S A. 2014. PMID: 25316793 Free PMC article.
758 results