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USP7 small-molecule inhibitors interfere with ubiquitin binding.
Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, Bainbridge TW, Kwok MCM, Ma TP, Stiffler Z, Brasher B, Tang Y, Jaishankar P, Hearn BR, Renslo AR, Arkin MR, Cohen F, Yu K, Peale F, Gnad F, Chang MT, Klijn C, Blackwood E, Martin SE, Forrest WF, Ernst JA, Ndubaku C, Wang X, Beresini MH, Tsui V, Schwerdtfeger C, Blake RA, Murray J, Maurer T, Wertz IE. Kategaya L, et al. Among authors: schwerdtfeger c. Nature. 2017 Oct 26;550(7677):534-538. doi: 10.1038/nature24006. Epub 2017 Oct 18. Nature. 2017. PMID: 29045385
Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.
Hewings DS, Heideker J, Ma TP, AhYoung AP, El Oualid F, Amore A, Costakes GT, Kirchhofer D, Brasher B, Pillow T, Popovych N, Maurer T, Schwerdtfeger C, Forrest WF, Yu K, Flygare J, Bogyo M, Wertz IE. Hewings DS, et al. Among authors: schwerdtfeger c. Nat Commun. 2018 Mar 21;9(1):1162. doi: 10.1038/s41467-018-03511-6. Nat Commun. 2018. PMID: 29563501 Free PMC article.
Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W.
Davies CW, Vidal SE, Phu L, Sudhamsu J, Hinkle TB, Chan Rosenberg S, Schumacher FR, Zeng YJ, Schwerdtfeger C, Peterson AS, Lill JR, Rose CM, Shaw AS, Wertz IE, Kirkpatrick DS, Koerber JT. Davies CW, et al. Among authors: schwerdtfeger c. Nat Commun. 2021 Jul 29;12(1):4608. doi: 10.1038/s41467-021-24669-6. Nat Commun. 2021. PMID: 34326324 Free PMC article.
Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Teyra J, Singer AU, Schmitges FW, Jaynes P, Kit Leng Lui S, Polyak MJ, Fodil N, Krieger JR, Tong J, Schwerdtfeger C, Brasher BB, Ceccarelli DFJ, Moffat J, Sicheri F, Moran MF, Gros P, Eichhorn PJA, Lenter M, Boehmelt G, Sidhu SS. Teyra J, et al. Among authors: schwerdtfeger c. Structure. 2019 Apr 2;27(4):590-605.e5. doi: 10.1016/j.str.2019.01.002. Epub 2019 Jan 31. Structure. 2019. PMID: 30713027 Free article.
Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.
Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu SS. Pascoe N, et al. Among authors: schwerdtfeger c. J Mol Biol. 2019 Mar 15;431(6):1160-1171. doi: 10.1016/j.jmb.2019.02.007. Epub 2019 Feb 11. J Mol Biol. 2019. PMID: 30763569
A circadian clock in Neurospora: how genes and proteins cooperate to produce a sustained, entrainable, and compensated biological oscillator with a period of about a day.
Dunlap JC, Loros JJ, Colot HV, Mehra A, Belden WJ, Shi M, Hong CI, Larrondo LF, Baker CL, Chen CH, Schwerdtfeger C, Collopy PD, Gamsby JJ, Lambreghts R. Dunlap JC, et al. Among authors: schwerdtfeger c. Cold Spring Harb Symp Quant Biol. 2007;72:57-68. doi: 10.1101/sqb.2007.72.072. Cold Spring Harb Symp Quant Biol. 2007. PMID: 18522516 Free PMC article. Review.
46 results