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Advances in myogenic cell transplantation and skeletal muscle tissue engineering.
Scime A, Caron AZ, Grenier G. Scime A, et al. Front Biosci (Landmark Ed). 2009 Jan 1;14:3012-23. doi: 10.2741/3431. Front Biosci (Landmark Ed). 2009. PMID: 19273253 Review.
Despite the slow progress, these studies have provided insights and avenues that will eventually lead to a powerful therapeutic tool....
Despite the slow progress, these studies have provided insights and avenues that will eventually lead to a powerful therapeutic tool. …
Ste20-like kinase SLK displays myofiber type specificity and is involved in C2C12 myoblast differentiation.
Storbeck CJ, Daniel K, Zhang YH, Lunde J, Scime A, Asakura A, Jasmin B, Korneluk RG, Sabourin LA. Storbeck CJ, et al. Among authors: scime a. Muscle Nerve. 2004 Apr;29(4):553-64. doi: 10.1002/mus.20000. Muscle Nerve. 2004. PMID: 15052621
We have recently cloned and characterized a novel Ste20-like kinase termed SLK that is associated with adhesion structures during cell adhesion and spreading. ...Supporting a role in myoblast function and differentiation, SLK expression is induced in Myf5- and Pax7- …
We have recently cloned and characterized a novel Ste20-like kinase termed SLK that is associated with adhesion structures during cel …
Pax7 is necessary and sufficient for the myogenic specification of CD45+:Sca1+ stem cells from injured muscle.
Seale P, Ishibashi J, Scimè A, Rudnicki MA. Seale P, et al. Among authors: scime a. PLoS Biol. 2004 May;2(5):E130. doi: 10.1371/journal.pbio.0020130. Epub 2004 May 11. PLoS Biol. 2004. PMID: 15138500 Free PMC article.
Moreover, these experiments suggest that viral transduction of Pax7 is a potential therapeutic approach for the treatment of neuromuscular degenerative diseases....
Moreover, these experiments suggest that viral transduction of Pax7 is a potential therapeutic approach for the treatment of neuromus …
Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation.
Huh MS, Parker MH, Scimè A, Parks R, Rudnicki MA. Huh MS, et al. Among authors: scime a. J Cell Biol. 2004 Sep 13;166(6):865-76. doi: 10.1083/jcb.200403004. J Cell Biol. 2004. PMID: 15364961 Free PMC article.
To investigate the requirement for pRb in myogenic differentiation, a floxed Rb allele was deleted either in proliferating myoblasts or after differentiation. ...In contrast, MCK-Cre mice, lacking pRb in differentiated fibers, were viable and exhibited a normal musc …
To investigate the requirement for pRb in myogenic differentiation, a floxed Rb allele was deleted either in proliferating myoblasts …
Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha.
Scimè A, Grenier G, Huh MS, Gillespie MA, Bevilacqua L, Harper ME, Rudnicki MA. Scimè A, et al. Cell Metab. 2005 Nov;2(5):283-95. doi: 10.1016/j.cmet.2005.10.002. Cell Metab. 2005. PMID: 16271529
We report here that mice lacking p107 displayed a uniform replacement of white adipose tissue (WAT) with brown adipose tissue (BAT). ...Therefore, p107 and pRb regulate PGC-1alpha expression to control the switch between white and brown adipocyte differentiation from a
We report here that mice lacking p107 displayed a uniform replacement of white adipose tissue (WAT) with brown adipose tissue (BAT). …
Anabolic potential and regulation of the skeletal muscle satellite cell populations.
Scimè A, Rudnicki MA. Scimè A, et al. Curr Opin Clin Nutr Metab Care. 2006 May;9(3):214-9. doi: 10.1097/01.mco.0000222102.21385.7d. Curr Opin Clin Nutr Metab Care. 2006. PMID: 16607119 Review.
An understanding of the mechanisms that increase their number is important for potential therapeutic use in a variety of muscle disorders. ...We also highlight our current knowledge of satellite cell specification that provides a potential basis for increasing satel …
An understanding of the mechanisms that increase their number is important for potential therapeutic use in a variety of muscle disor …
Resident endothelial precursors in muscle, adipose, and dermis contribute to postnatal vasculogenesis.
Grenier G, Scimè A, Le Grand F, Asakura A, Perez-Iratxeta C, Andrade-Navarro MA, Labosky PA, Rudnicki MA. Grenier G, et al. Among authors: scime a. Stem Cells. 2007 Dec;25(12):3101-10. doi: 10.1634/stemcells.2006-0795. Epub 2007 Sep 6. Stem Cells. 2007. PMID: 17823241
A novel population of tissue-resident endothelial precursors (TEPs) was isolated from small blood vessels in dermal, adipose, and skeletal muscle of mouse based on their ability to be grown as spheres. ...Taken together, these experiments suggest that TEPs represent a
A novel population of tissue-resident endothelial precursors (TEPs) was isolated from small blood vessels in dermal, adipose, and ske
Molecular-targeted therapy for Duchenne muscular dystrophy: progress and potential.
Scimè A, Rudnicki MA. Scimè A, et al. Mol Diagn Ther. 2008;12(2):99-108. doi: 10.1007/BF03256275. Mol Diagn Ther. 2008. PMID: 18422374 Review.
Duchenne muscular dystrophy (DMD) is a lethal heritable childhood myodegenerative condition caused by a mutation within the gene encoding the dystrophin protein within the X chromosome. While, historically, patients with this condition rarely lived into their thirti …
Duchenne muscular dystrophy (DMD) is a lethal heritable childhood myodegenerative condition caused by a mutation within the ge …
PRDM16 controls a brown fat/skeletal muscle switch.
Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. Seale P, et al. Among authors: scime a. Nature. 2008 Aug 21;454(7207):961-7. doi: 10.1038/nature07182. Nature. 2008. PMID: 18719582 Free PMC article.
Brown fat can increase energy expenditure and protect against obesity through a specialized program of uncoupled respiration. ...Taken together, these data indicate that PRDM16 specifies the brown fat lineage from a progenitor that expresses myoblast markers and is …
Brown fat can increase energy expenditure and protect against obesity through a specialized program of uncoupled respiration. ...Take …
Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells.
Le Grand F, Jones AE, Seale V, Scimè A, Rudnicki MA. Le Grand F, et al. Among authors: scime a. Cell Stem Cell. 2009 Jun 5;4(6):535-47. doi: 10.1016/j.stem.2009.03.013. Cell Stem Cell. 2009. PMID: 19497282 Free PMC article.
Satellite cells in skeletal muscle are a heterogeneous population of stem cells and committed progenitors. We found that quiescent satellite stem cells expressed the Wnt receptor Fzd7 and that its candidate ligand Wnt7a was upregulated during regeneration. ...Muscle lackin …
Satellite cells in skeletal muscle are a heterogeneous population of stem cells and committed progenitors. We found that quiescent sa …
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