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A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.
Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ. Steward-Tharp SM, et al. Among authors: sciume g. Blood. 2014 May 8;123(19):2978-87. doi: 10.1182/blood-2013-09-523167. Epub 2014 Mar 14. Blood. 2014. PMID: 24632714 Free PMC article.
Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1.
Hirahara K, Ghoreschi K, Yang XP, Takahashi H, Laurence A, Vahedi G, Sciumè G, Hall AO, Dupont CD, Francisco LM, Chen Q, Tanaka M, Kanno Y, Sun HW, Sharpe AH, Hunter CA, O'Shea JJ. Hirahara K, et al. Among authors: sciume g. Immunity. 2012 Jun 29;36(6):1017-30. doi: 10.1016/j.immuni.2012.03.024. Epub 2012 Jun 21. Immunity. 2012. PMID: 22726954 Free PMC article.
Distinct requirements for T-bet in gut innate lymphoid cells.
Sciumé G, Hirahara K, Takahashi H, Laurence A, Villarino AV, Singleton KL, Spencer SP, Wilhelm C, Poholek AC, Vahedi G, Kanno Y, Belkaid Y, O'Shea JJ. Sciumé G, et al. J Exp Med. 2012 Dec 17;209(13):2331-8. doi: 10.1084/jem.20122097. Epub 2012 Dec 3. J Exp Med. 2012. PMID: 23209316 Free PMC article.
BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.
Roychoudhuri R, Hirahara K, Mousavi K, Clever D, Klebanoff CA, Bonelli M, Sciumè G, Zare H, Vahedi G, Dema B, Yu Z, Liu H, Takahashi H, Rao M, Muranski P, Crompton JG, Punkosdy G, Bedognetti D, Wang E, Hoffmann V, Rivera J, Marincola FM, Nakamura A, Sartorelli V, Kanno Y, Gattinoni L, Muto A, Igarashi K, O'Shea JJ, Restifo NP. Roychoudhuri R, et al. Among authors: sciume g. Nature. 2013 Jun 27;498(7455):506-10. doi: 10.1038/nature12199. Epub 2013 Jun 2. Nature. 2013. PMID: 23728300 Free PMC article.
Transcriptional and epigenetic networks of helper T and innate lymphoid cells.
Shih HY, Sciumè G, Poholek AC, Vahedi G, Hirahara K, Villarino AV, Bonelli M, Bosselut R, Kanno Y, Muljo SA, O'Shea JJ. Shih HY, et al. Among authors: sciume g. Immunol Rev. 2014 Sep;261(1):23-49. doi: 10.1111/imr.12208. Immunol Rev. 2014. PMID: 25123275 Free PMC article. Review.
Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.
Hirahara K, Onodera A, Villarino AV, Bonelli M, Sciumè G, Laurence A, Sun HW, Brooks SR, Vahedi G, Shih HY, Gutierrez-Cruz G, Iwata S, Suzuki R, Mikami Y, Okamoto Y, Nakayama T, Holland SM, Hunter CA, Kanno Y, O'Shea JJ. Hirahara K, et al. Among authors: sciume g. Immunity. 2015 May 19;42(5):877-89. doi: 10.1016/j.immuni.2015.04.014. Immunity. 2015. PMID: 25992861 Free article.
Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction.
Furumoto Y, Smith CK, Blanco L, Zhao W, Brooks SR, Thacker SG, Abdalrahman Z, Sciumè G, Tsai WL, Trier AM, Nunez L, Mast L, Hoffmann V, Remaley AT, O'Shea JJ, Kaplan MJ, Gadina M. Furumoto Y, et al. Among authors: sciume g. Arthritis Rheumatol. 2017 Jan;69(1):148-160. doi: 10.1002/art.39818. Arthritis Rheumatol. 2017. PMID: 27429362 Free PMC article.
65 results