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Neuropeptides in tendinopathy.
Scott A, Bahr R. Scott A, et al. Front Biosci (Landmark Ed). 2009 Jan 1;14:2203-11. doi: 10.2741/3372. Front Biosci (Landmark Ed). 2009. PMID: 19273194 Free PMC article. Review.
Overuse tendinopathy remains a major clinical burden for sports medicine and general practitioners. Recent studies have highlighted the role of sensory and autonomic nerves in generating or perpetuating the symptoms and tissue abnormalities associated with tendinopathy. .. …
Overuse tendinopathy remains a major clinical burden for sports medicine and general practitioners. Recent studies have highlighted t …
What do we mean by the term "inflammation"? A contemporary basic science update for sports medicine.
Scott A, Khan KM, Roberts CR, Cook JL, Duronio V. Scott A, et al. Br J Sports Med. 2004 Jun;38(3):372-80. doi: 10.1136/bjsm.2004.011312. Br J Sports Med. 2004. PMID: 15155453 Free PMC article. Review.
Most practicing sports medicine clinicians refer to the concept of "inflammation" many times a day when diagnosing and treating acute and overuse injuries. ...Is it a "good" or a "bad" process? The major advances in the understanding of inflammation in recent …
Most practicing sports medicine clinicians refer to the concept of "inflammation" many times a day when diagnosing and treating acute …
Common tendinopathies in the upper and lower extremities.
Scott A, Ashe MC. Scott A, et al. Curr Sports Med Rep. 2006 Sep;5(5):233-41. doi: 10.1097/01.csmr.0000306421.85919.9c. Curr Sports Med Rep. 2006. PMID: 16934204 Review.
Overuse tendon injuries (tendinopathies) present a challenge to sports medicine patients and clinicians. Despite the high prevalence of tendinopathy in recreational and competitive athletes, treatment is often hampered by contradictory definitions and descriptions of the u …
Overuse tendon injuries (tendinopathies) present a challenge to sports medicine patients and clinicians. Despite the high prevalence …
Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats.
Scott A, Cook JL, Hart DA, Walker DC, Duronio V, Khan KM. Scott A, et al. Arthritis Rheum. 2007 Mar;56(3):871-81. doi: 10.1002/art.22426. Arthritis Rheum. 2007. PMID: 17328060
METHODS: Supraspinatus tendinosis was induced by running rats downhill at 1 km/hour for 1 hour a day. Tendons were harvested at 4, 8, 12, and 16 weeks and processed for brightfield, polarized light, or transmission electron microscopy. ...Our data suggest a role for …
METHODS: Supraspinatus tendinosis was induced by running rats downhill at 1 km/hour for 1 hour a day. Tendons were harvested at 4, 8, …
Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee.
Scott A, Lian Ø, Roberts CR, Cook JL, Handley CJ, Bahr R, Samiric T, Ilic MZ, Parkinson J, Hart DA, Duronio V, Khan KM. Scott A, et al. Scand J Med Sci Sports. 2008 Aug;18(4):427-35. doi: 10.1111/j.1600-0838.2007.00735.x. Epub 2007 Dec 7. Scand J Med Sci Sports. 2008. PMID: 18067512 Free PMC article.
Expansion of the extracellular matrix is a prominent but poorly characterized feature of tendinosis. The present study aimed to characterize the extent and distribution of the large aggregating proteoglycan versican in patients with patellar tendinosis. ...Versican deposit …
Expansion of the extracellular matrix is a prominent but poorly characterized feature of tendinosis. The present study aimed to chara …
Mechanotransduction in human bone: in vitro cellular physiology that underpins bone changes with exercise.
Scott A, Khan KM, Duronio V, Hart DA. Scott A, et al. Sports Med. 2008;38(2):139-60. doi: 10.2165/00007256-200838020-00004. Sports Med. 2008. PMID: 18201116 Free PMC article. Review.
Bone has a remarkable ability to adjust its mass and architecture in response to a wide range of loads, from low-level gravitational forces to high-level impacts. A variety of types and magnitudes of mechanical stimuli have been shown to influence human bone …
Bone has a remarkable ability to adjust its mass and architecture in response to a wide range of loads, from low-level gravita …
Increased mast cell numbers in human patellar tendinosis: correlation with symptom duration and vascular hyperplasia.
Scott A, Lian Ø, Bahr R, Hart DA, Duronio V, Khan KM. Scott A, et al. Br J Sports Med. 2008 Sep;42(9):753-7. doi: 10.1136/bjsm.2007.040212. Epub 2008 Feb 28. Br J Sports Med. 2008. PMID: 18308880
METHODS: Tendinopathic tissue was collected at open debridement of the patellar tendon and a control tendon from patients undergoing intramedullary nailing of the tibia. ...
METHODS: Tendinopathic tissue was collected at open debridement of the patellar tendon and a control tendon from patients undergoing …
Mechanotherapy: how physical therapists' prescription of exercise promotes tissue repair.
Khan KM, Scott A. Khan KM, et al. Br J Sports Med. 2009 Apr;43(4):247-52. doi: 10.1136/bjsm.2008.054239. Epub 2009 Feb 24. Br J Sports Med. 2009. PMID: 19244270 Free PMC article. Review.
The purpose of this short article is to answer a frequently asked question "How precisely does exercise promote tissue healing?" This is a fundamental question for clinicians who prescribe exercise for tendinopathies, muscle tears, non-inflammatory arthropathies and …
The purpose of this short article is to answer a frequently asked question "How precisely does exercise promote tissue healing?" This …
Scleraxis expression is coordinately regulated in a murine model of patellar tendon injury.
Scott A, Sampaio A, Abraham T, Duronio C, Underhill TM. Scott A, et al. J Orthop Res. 2011 Feb;29(2):289-96. doi: 10.1002/jor.21220. Epub 2010 Aug 25. J Orthop Res. 2011. PMID: 20740671 Free PMC article.
This study investigated the expression of Scleraxis in a murine model of patellar tendon injury in which the central third of the patellar tendon was unilaterally injured. ...Tendon pathology was also quantified noninvasively over a 12-week period using high-frequen …
This study investigated the expression of Scleraxis in a murine model of patellar tendon injury in which the central third of the pat …
Second harmonic generation analysis of early Achilles tendinosis in response to in vivo mechanical loading.
Abraham T, Fong G, Scott A. Abraham T, et al. BMC Musculoskelet Disord. 2011 Jan 26;12:26. doi: 10.1186/1471-2474-12-26. BMC Musculoskelet Disord. 2011. PMID: 21269488 Free PMC article.
BACKGROUND: Tenocytes have been implicated in the development of tendinosis, a chronic condition commonly seen in musculoskeletal overuse syndromes. ...Second harmonic generation (SHG) microscopy is a recently developed technique which allows examination of fibrilla …
BACKGROUND: Tenocytes have been implicated in the development of tendinosis, a chronic condition commonly seen in musculoskeletal ove …
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