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34 results
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Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.
Al-Riyami L, Pineda MA, Rzepecka J, Huggan JK, Khalaf AI, Suckling CJ, Scott FJ, Rodgers DT, Harnett MM, Harnett W. Al-Riyami L, et al. Among authors: scott fj. J Med Chem. 2013 Dec 27;56(24):9982-10002. doi: 10.1021/jm401251p. Epub 2013 Nov 25. J Med Chem. 2013. PMID: 24228757 Free PMC article.
Selective anti-malarial minor groove binders.
Scott FJ, Khalaf AI, Duffy S, Avery VM, Suckling CJ. Scott FJ, et al. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3326-3329. doi: 10.1016/j.bmcl.2016.05.039. Epub 2016 May 13. Bioorg Med Chem Lett. 2016. PMID: 27212070
An evaluation of Minor Groove Binders as anti-lung cancer therapeutics.
Scott FJ, Puig-Sellart M, Khalaf AI, Henderson CJ, Westrop G, Watson DG, Carter K, Grant MH, Suckling CJ. Scott FJ, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3478-86. doi: 10.1016/j.bmcl.2016.06.040. Epub 2016 Jun 16. Bioorg Med Chem Lett. 2016. PMID: 27349332
An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics.
Scott FJ, Nichol RJO, Khalaf AI, Giordani F, Gillingwater K, Ramu S, Elliott A, Zuegg J, Duffy P, Rosslee MJ, Hlaka L, Kumar S, Ozturk M, Brombacher F, Barrett M, Guler R, Suckling CJ. Scott FJ, et al. Eur J Med Chem. 2017 Aug 18;136:561-572. doi: 10.1016/j.ejmech.2017.05.039. Epub 2017 May 17. Eur J Med Chem. 2017. PMID: 28544982
Selective in vitro anti-cancer activity of non-alkylating minor groove binders.
Nichol RJO, Khalaf AI, Sooda K, Hussain O, Griffiths HBS, Phillips R, Javid FA, Suckling CJ, Allison SJ, Scott FJ. Nichol RJO, et al. Among authors: scott fj. Medchemcomm. 2019 Jul 18;10(9):1620-1634. doi: 10.1039/c9md00268e. eCollection 2019 Sep 1. Medchemcomm. 2019. PMID: 32952999 Free PMC article.
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