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Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR.
Horigan G, McNulty H, Ward M, Strain JJ, Purvis J, Scott JM. Horigan G, et al. Among authors: scott jm. J Hypertens. 2010 Mar;28(3):478-86. doi: 10.1097/HJH.0b013e328334c126. J Hypertens. 2010. PMID: 19952781
Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study.
Kirke PN, Mills JL, Molloy AM, Brody LC, O'Leary VB, Daly L, Murray S, Conley M, Mayne PD, Smith O, Scott JM. Kirke PN, et al. Among authors: scott jm. BMJ. 2004 Jun 26;328(7455):1535-6. doi: 10.1136/bmj.38036.646030.EE. Epub 2004 May 21. BMJ. 2004. PMID: 15155469 Free PMC article. No abstract available.
MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae.
Parle-McDermott A, Mills JL, Kirke PN, Cox C, Signore CC, Kirke S, Molloy AM, O'Leary VB, Pangilinan FJ, O'Herlihy C, Brody LC, Scott JM. Parle-McDermott A, et al. Among authors: scott jm. Am J Med Genet A. 2005 Feb 1;132A(4):365-8. doi: 10.1002/ajmg.a.30354. Am J Med Genet A. 2005. PMID: 15633187
The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men.
Pentieva K, McNulty H, Reichert R, Ward M, Strain JJ, McKillop DJ, McPartlin JM, Connolly E, Molloy A, Krämer K, Scott JM. Pentieva K, et al. Among authors: scott jm. J Nutr. 2004 Mar;134(3):580-5. doi: 10.1093/jn/134.3.580. J Nutr. 2004. PMID: 14988450 Clinical Trial.
Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial.
Wilson CP, McNulty H, Ward M, Strain JJ, Trouton TG, Hoeft BA, Weber P, Roos FF, Horigan G, McAnena L, Scott JM. Wilson CP, et al. Among authors: scott jm. Hypertension. 2013 Jun;61(6):1302-8. doi: 10.1161/HYPERTENSIONAHA.111.01047. Epub 2013 Apr 22. Hypertension. 2013. PMID: 23608654 Clinical Trial.
B-vitamins, methylenetetrahydrofolate reductase (MTHFR) and hypertension.
Ward M, Wilson CP, Strain JJ, Horigan G, Scott JM, McNulty H. Ward M, et al. Among authors: scott jm. Int J Vitam Nutr Res. 2011 Jul;81(4):240-4. doi: 10.1024/0300-9831/a000069. Int J Vitam Nutr Res. 2011. PMID: 22237773
Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.
Hammons AL, Summers CM, Woodside JV, McNulty H, Strain JJ, Young IS, Murray L, Boreham CA, Scott JM, Mitchell LE, Whitehead AS. Hammons AL, et al. Among authors: scott jm. Clin Immunol. 2009 Oct;133(1):132-7. doi: 10.1016/j.clim.2009.06.008. Epub 2009 Jul 21. Clin Immunol. 2009. PMID: 19625220 Free PMC article.
The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels.
Parle-McDermott A, Mills JL, Molloy AM, Carroll N, Kirke PN, Cox C, Conley MR, Pangilinan FJ, Brody LC, Scott JM. Parle-McDermott A, et al. Among authors: scott jm. Mol Genet Metab. 2006 Jul;88(3):290-4. doi: 10.1016/j.ymgme.2006.02.011. Epub 2006 Apr 18. Mol Genet Metab. 2006. PMID: 16621645
Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism.
McNulty H, Dowey le RC, Strain JJ, Dunne A, Ward M, Molloy AM, McAnena LB, Hughes JP, Hannon-Fletcher M, Scott JM. McNulty H, et al. Among authors: scott jm. Circulation. 2006 Jan 3;113(1):74-80. doi: 10.1161/CIRCULATIONAHA.105.580332. Epub 2005 Dec 27. Circulation. 2006. PMID: 16380544 Clinical Trial.
Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements.
McNulty H, McKinley MC, Wilson B, McPartlin J, Strain JJ, Weir DG, Scott JM. McNulty H, et al. Among authors: scott jm. Am J Clin Nutr. 2002 Aug;76(2):436-41. doi: 10.1093/ajcn/76.2.436. Am J Clin Nutr. 2002. PMID: 12145019 Clinical Trial.
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