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Management of cellular energy by the AMP-activated protein kinase system.
Hardie DG, Scott JW, Pan DA, Hudson ER. Hardie DG, et al. FEBS Lett. 2003 Jul 3;546(1):113-20. doi: 10.1016/s0014-5793(03)00560-x. FEBS Lett. 2003. PMID: 12829246 Review.
Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase.
Akman HO, Sampayo JN, Ross FA, Scott JW, Wilson G, Benson L, Bruno C, Shanske S, Hardie DG, Dimauro S. Akman HO, et al. Pediatr Res. 2007 Oct;62(4):499-504. doi: 10.1203/PDR.0b013e3181462b86. Pediatr Res. 2007. PMID: 17667862
Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency.
Burwinkel B, Scott JW, Bührer C, van Landeghem FK, Cox GF, Wilson CJ, Grahame Hardie D, Kilimann MW. Burwinkel B, et al. Am J Hum Genet. 2005 Jun;76(6):1034-49. doi: 10.1086/430840. Epub 2005 May 2. Am J Hum Genet. 2005. PMID: 15877279 Free PMC article.
AMP-activated protein kinase--development of the energy sensor concept.
Hardie DG, Hawley SA, Scott JW. Hardie DG, et al. J Physiol. 2006 Jul 1;574(Pt 1):7-15. doi: 10.1113/jphysiol.2006.108944. Epub 2006 Apr 27. J Physiol. 2006. PMID: 16644800 Free PMC article. Review.
Analysis of the LKB1-STRAD-MO25 complex.
Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR. Boudeau J, et al. J Cell Sci. 2004 Dec 15;117(Pt 26):6365-75. doi: 10.1242/jcs.01571. Epub 2004 Nov 23. J Cell Sci. 2004. PMID: 15561763
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.
Scott JW, Hawley SA, Green KA, Anis M, Stewart G, Scullion GA, Norman DG, Hardie DG. Scott JW, et al. J Clin Invest. 2004 Jan;113(2):274-84. doi: 10.1172/JCI19874. J Clin Invest. 2004. PMID: 14722619 Free PMC article.
β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase.
Ali N, Ling N, Krishnamurthy S, Oakhill JS, Scott JW, Stapleton DI, Kemp BE, Anand GS, Gooley PR. Ali N, et al. Sci Rep. 2016 Dec 21;6:39417. doi: 10.1038/srep39417. Sci Rep. 2016. PMID: 28000716 Free PMC article.
Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.
Scott JW, Ling N, Issa SM, Dite TA, O'Brien MT, Chen ZP, Galic S, Langendorf CG, Steinberg GR, Kemp BE, Oakhill JS. Scott JW, et al. Chem Biol. 2014 May 22;21(5):619-27. doi: 10.1016/j.chembiol.2014.03.006. Epub 2014 Apr 17. Chem Biol. 2014. PMID: 24746562
ATP sensitive bi-quinoline activator of the AMP-activated protein kinase.
Scott JW, Oakhill JS, Ling NX, Langendorf CG, Foitzik RC, Kemp BE, Issinger OG. Scott JW, et al. Biochem Biophys Res Commun. 2014 Jan 10;443(2):435-40. doi: 10.1016/j.bbrc.2013.11.130. Epub 2013 Dec 8. Biochem Biophys Res Commun. 2014. PMID: 24332941
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