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An anti-infective peptide that selectively modulates the innate immune response.
Scott MG, Dullaghan E, Mookherjee N, Glavas N, Waldbrook M, Thompson A, Wang A, Lee K, Doria S, Hamill P, Yu JJ, Li Y, Donini O, Guarna MM, Finlay BB, North JR, Hancock RE. Scott MG, et al. Nat Biotechnol. 2007 Apr;25(4):465-72. doi: 10.1038/nbt1288. Epub 2007 Mar 25. Nat Biotechnol. 2007. PMID: 17384586
Design of host defence peptides for antimicrobial and immunity enhancing activities.
McPhee JB, Scott MG, Hancock RE. McPhee JB, et al. Among authors: scott mg. Comb Chem High Throughput Screen. 2005 May;8(3):257-72. doi: 10.2174/1386207053764558. Comb Chem High Throughput Screen. 2005. PMID: 15892627 Review.
Immunomodulatory activities of small host defense peptides.
Bowdish DM, Davidson DJ, Scott MG, Hancock RE. Bowdish DM, et al. Among authors: scott mg. Antimicrob Agents Chemother. 2005 May;49(5):1727-32. doi: 10.1128/AAC.49.5.1727-1732.2005. Antimicrob Agents Chemother. 2005. PMID: 15855488 Free PMC article.
Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells.
Lau YE, Rozek A, Scott MG, Goosney DL, Davidson DJ, Hancock RE. Lau YE, et al. Among authors: scott mg. Infect Immun. 2005 Jan;73(1):583-91. doi: 10.1128/IAI.73.1.583-591.2005. Infect Immun. 2005. PMID: 15618198 Free PMC article.
Impact of LL-37 on anti-infective immunity.
Bowdish DM, Davidson DJ, Lau YE, Lee K, Scott MG, Hancock RE. Bowdish DM, et al. Among authors: scott mg. J Leukoc Biol. 2005 Apr;77(4):451-9. doi: 10.1189/jlb.0704380. Epub 2004 Nov 29. J Leukoc Biol. 2005. PMID: 15569695 Review.
An alpha-helical cationic antimicrobial peptide selectively modulates macrophage responses to lipopolysaccharide and directly alters macrophage gene expression.
Scott MG, Rosenberger CM, Gold MR, Finlay BB, Hancock RE. Scott MG, et al. J Immunol. 2000 Sep 15;165(6):3358-65. doi: 10.4049/jimmunol.165.6.3358. J Immunol. 2000. PMID: 10975854
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