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Prion protein biology.
Prusiner SB, Scott MR, DeArmond SJ, Cohen FE. Prusiner SB, et al. Cell. 1998 May 1;93(3):337-48. doi: 10.1016/s0092-8674(00)81163-0. Cell. 1998. PMID: 9590169 Review. No abstract available.
Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells.
Karpuj MV, Giles K, Gelibter-Niv S, Scott MR, Lingappa VR, Szoka FC, Peretz D, Denetclaw W, Prusiner SB. Karpuj MV, et al. Mol Med. 2007 Mar-Apr;13(3-4):190-8. doi: 10.2119/2006–00073.Karpuj. Mol Med. 2007. PMID: 17592554 Free PMC article.
A change in the conformation of prions accompanies the emergence of a new prion strain.
Peretz D, Williamson RA, Legname G, Matsunaga Y, Vergara J, Burton DR, DeArmond SJ, Prusiner SB, Scott MR. Peretz D, et al. Neuron. 2002 Jun 13;34(6):921-32. doi: 10.1016/s0896-6273(02)00726-2. Neuron. 2002. PMID: 12086640
Transmission barriers for bovine, ovine, and human prions in transgenic mice.
Scott MR, Peretz D, Nguyen HO, Dearmond SJ, Prusiner SB. Scott MR, et al. J Virol. 2005 May;79(9):5259-71. doi: 10.1128/JVI.79.9.5259-5271.2005. J Virol. 2005. PMID: 15827140 Free PMC article.
Strain-specified relative conformational stability of the scrapie prion protein.
Peretz D, Scott MR, Groth D, Williamson RA, Burton DR, Cohen FE, Prusiner SB. Peretz D, et al. Protein Sci. 2001 Apr;10(4):854-63. doi: 10.1110/ps.39201. Protein Sci. 2001. PMID: 11274476 Free PMC article.
Branched polyamines cure prion-infected neuroblastoma cells.
Supattapone S, Wille H, Uyechi L, Safar J, Tremblay P, Szoka FC, Cohen FE, Prusiner SB, Scott MR. Supattapone S, et al. J Virol. 2001 Apr;75(7):3453-61. doi: 10.1128/JVI.75.7.3453-3461.2001. J Virol. 2001. PMID: 11238871 Free PMC article.
Scott, Proc. Natl. Acad. Sci. USA 96:14529-14534, 1999). We now demonstrate that exposure of ScN2a cells to 3 microg of PPI generation 4.0/ml for 4 weeks not only reduced PrP(Sc) to a level undetectable by Western blot but also eradicated prion infectivity as determined by
Scott, Proc. Natl. Acad. Sci. USA 96:14529-14534, 1999). We now demonstrate that exposure of ScN2a cells to 3 microg of PPI generatio
Transgenic models of prion disease.
Scott MR, Supattapone S, Nguyen HO, DeArmond SJ, Prusiner SB. Scott MR, et al. Arch Virol Suppl. 2000;(16):113-24. doi: 10.1007/978-3-7091-6308-5_10. Arch Virol Suppl. 2000. PMID: 11214913 Review.
Identification of two prion protein regions that modify scrapie incubation time.
Supattapone S, Muramoto T, Legname G, Mehlhorn I, Cohen FE, DeArmond SJ, Prusiner SB, Scott MR. Supattapone S, et al. J Virol. 2001 Feb;75(3):1408-13. doi: 10.1128/JVI.75.3.1408-1413.2001. J Virol. 2001. PMID: 11152514 Free PMC article.
Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans.
Scott MR, Will R, Ironside J, Nguyen HO, Tremblay P, DeArmond SJ, Prusiner SB. Scott MR, et al. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15137-42. doi: 10.1073/pnas.96.26.15137. Proc Natl Acad Sci U S A. 1999. PMID: 10611351 Free PMC article.
Elimination of prions by branched polyamines and implications for therapeutics.
Supattapone S, Nguyen HO, Cohen FE, Prusiner SB, Scott MR. Supattapone S, et al. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14529-34. doi: 10.1073/pnas.96.25.14529. Proc Natl Acad Sci U S A. 1999. PMID: 10588739 Free PMC article.
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