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Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.
Scozzafava A, Menabuoni L, Mincione F, Supuran CT. Scozzafava A, et al. J Med Chem. 2002 Mar 28;45(7):1466-76. doi: 10.1021/jm0108202. J Med Chem. 2002. PMID: 11906288
Carbonic Anhydrase Inhibitors Part 72 Synthesis and Antiglaucoma Properties of Metal Complexes of p-Fluorobenzolamide.
Supuran CT, Scozzafava A, Menabuoni L, Mincione F, Briganti F, Mincione G. Supuran CT, et al. Among authors: scozzafava a. Met Based Drugs. 1999;6(2):67-73. doi: 10.1155/MBD.1999.67. Met Based Drugs. 1999. PMID: 18475883 Free PMC article.
Carbonic Anhydrase Inhibitors. Part 55 Metal Complexes of 1,3,4-Thiadiazole-2-Sulfonamide Derivatives: In Vitro Inhibition Studies With Carbonic Anhydrase Isozymes I, II and IV.
Supuran CT, Scozzafava A, Briganti F, Ilies MA, Jitianu A. Supuran CT, et al. Among authors: scozzafava a. Met Based Drugs. 1998;5(2):103-14. doi: 10.1155/MBD.1998.103. Met Based Drugs. 1998. PMID: 18475829 Free PMC article.
Complexes with biologically active ligands. Part 11. Synthesis and carbonic anhydrase inhibitory activity of metal complexes of 4,5-disubstituted-3-mercapto-1,2,4-triazole derivatives.
Scozzafava A, Cavazza C, Supuran CT, Saramet I, Briganti F, Banciu MD. Scozzafava A, et al. Met Based Drugs. 1998;5(1):11-8. doi: 10.1155/MBD.1998.11. Met Based Drugs. 1998. PMID: 18475819 Free PMC article.
Carbonic Anhydrase Activators. Part 19 Spectroscopic and Kinetic Investigations for the Interaction of Isozymes I and II With Primary Amines.
Briganti F, Scozzafava A, Supuran CT. Briganti F, et al. Among authors: scozzafava a. Met Based Drugs. 1997;4(4):221-7. doi: 10.1155/MBD.1997.221. Met Based Drugs. 1997. PMID: 18475791 Free PMC article.
Purification, biochemical properties and substrate specificity of a catechol 1,2-dioxygenase from a phenol degrading Acinetobacter radioresistens.
Briganti F, Pessione E, Giunta C, Scozzafava A. Briganti F, et al. Among authors: scozzafava a. FEBS Lett. 1997 Oct 13;416(1):61-4. doi: 10.1016/s0014-5793(97)01167-8. FEBS Lett. 1997. PMID: 9369233
Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus.
Canto de Souza L, Provensi G, Vullo D, Carta F, Scozzafava A, Costa A, Schmidt SD, Passani MB, Supuran CT, Blandina P. Canto de Souza L, et al. Among authors: scozzafava a. Neuropharmacology. 2017 May 15;118:148-156. doi: 10.1016/j.neuropharm.2017.03.009. Epub 2017 Mar 9. Neuropharmacology. 2017. PMID: 28286213
Anion inhibition studies of two α-carbonic anhydrases from Lotus japonicus, LjCAA1 and LjCAA2.
Vullo D, Flemetakis E, Scozzafava A, Capasso C, Supuran CT. Vullo D, et al. Among authors: scozzafava a. J Inorg Biochem. 2014 Jul;136:67-72. doi: 10.1016/j.jinorgbio.2014.03.014. Epub 2014 Apr 8. J Inorg Biochem. 2014. PMID: 24769135
7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.
Tanc M, Carta F, Bozdag M, Scozzafava A, Supuran CT. Tanc M, et al. Among authors: scozzafava a. Bioorg Med Chem. 2013 Aug 1;21(15):4502-10. doi: 10.1016/j.bmc.2013.05.032. Epub 2013 May 31. Bioorg Med Chem. 2013. PMID: 23769167
Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors.
Trabocchi A, Pala N, Krimmelbein I, Menchi G, Guarna A, Sechi M, Dreker T, Scozzafava A, Supuran CT, Carta F. Trabocchi A, et al. Among authors: scozzafava a. J Enzyme Inhib Med Chem. 2015 Jun;30(3):466-71. doi: 10.3109/14756366.2014.947976. Epub 2014 Sep 8. J Enzyme Inhib Med Chem. 2015. PMID: 25198885
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