Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

568 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Carta F, Temperini C, Innocenti A, Scozzafava A, Kaila K, Supuran CT. Carta F, et al. Among authors: scozzafava a. J Med Chem. 2010 Aug 12;53(15):5511-22. doi: 10.1021/jm1003667. J Med Chem. 2010. PMID: 20590092
Spermine anchors to the nonprotein zinc ligand through a network of hydrogen bonds. Its distal amine moiety makes hydrogen bonds with residues Thr200 and Pro201, which further stabilize the adduct. Spermine binds differently compared to sulfonamides, phenols, or coumarins, …
Spermine anchors to the nonprotein zinc ligand through a network of hydrogen bonds. Its distal amine moiety makes hydrogen bonds with …
Carbonic Anhydrase Inhibitors Part 72 Synthesis and Antiglaucoma Properties of Metal Complexes of p-Fluorobenzolamide.
Supuran CT, Scozzafava A, Menabuoni L, Mincione F, Briganti F, Mincione G. Supuran CT, et al. Among authors: scozzafava a. Met Based Drugs. 1999;6(2):67-73. doi: 10.1155/MBD.1999.67. Met Based Drugs. 1999. PMID: 18475883 Free PMC article.
Metal complexes of a heterocyclic sulfonamides possessing very strong carbonic anhydrase (CA) inhibitory properties, i.e., 5-(p-fluorobenzenesulfonylamido)-1,3,4-thiadiazole-2-sulfonamide (p-fluorobenzolamide) were prepared. ...Some of these new complexes as well as the pa …
Metal complexes of a heterocyclic sulfonamides possessing very strong carbonic anhydrase (CA) inhibitory properties, i.e., 5-(p-fluor …
Carbonic Anhydrase Inhibitors. Part 55 Metal Complexes of 1,3,4-Thiadiazole-2-Sulfonamide Derivatives: In Vitro Inhibition Studies With Carbonic Anhydrase Isozymes I, II and IV.
Supuran CT, Scozzafava A, Briganti F, Ilies MA, Jitianu A. Supuran CT, et al. Among authors: scozzafava a. Met Based Drugs. 1998;5(2):103-14. doi: 10.1155/MBD.1998.103. Met Based Drugs. 1998. PMID: 18475829 Free PMC article.
Complexes with biologically active ligands. Part 11. Synthesis and carbonic anhydrase inhibitory activity of metal complexes of 4,5-disubstituted-3-mercapto-1,2,4-triazole derivatives.
Scozzafava A, Cavazza C, Supuran CT, Saramet I, Briganti F, Banciu MD. Scozzafava A, et al. Met Based Drugs. 1998;5(1):11-8. doi: 10.1155/MBD.1998.11. Met Based Drugs. 1998. PMID: 18475819 Free PMC article.
Carbonic Anhydrase Activators. Part 19 Spectroscopic and Kinetic Investigations for the Interaction of Isozymes I and II With Primary Amines.
Briganti F, Scozzafava A, Supuran CT. Briganti F, et al. Among authors: scozzafava a. Met Based Drugs. 1997;4(4):221-7. doi: 10.1155/MBD.1997.221. Met Based Drugs. 1997. PMID: 18475791 Free PMC article.
This is a direct spectroscopic evidence that the activator molecules bind within the active site, but not directly to the metal ion. ...
This is a direct spectroscopic evidence that the activator molecules bind within the active site, but not directly to the metal ion. …
Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus.
Canto de Souza L, Provensi G, Vullo D, Carta F, Scozzafava A, Costa A, Schmidt SD, Passani MB, Supuran CT, Blandina P. Canto de Souza L, et al. Among authors: scozzafava a. Neuropharmacology. 2017 May 15;118:148-156. doi: 10.1016/j.neuropharm.2017.03.009. Epub 2017 Mar 9. Neuropharmacology. 2017. PMID: 28286213
Anion inhibition studies of two α-carbonic anhydrases from Lotus japonicus, LjCAA1 and LjCAA2.
Vullo D, Flemetakis E, Scozzafava A, Capasso C, Supuran CT. Vullo D, et al. Among authors: scozzafava a. J Inorg Biochem. 2014 Jul;136:67-72. doi: 10.1016/j.jinorgbio.2014.03.014. Epub 2014 Apr 8. J Inorg Biochem. 2014. PMID: 24769135
LjCAA1 showed a high catalytic activity for the CO2 hydration reaction, with a k(cat) of 7.4∗10(5) s(-1) and a k(cat)/K(m) of 9.6∗10(7) M(-1) s(-1) and was inhibited in the low micromolar range by N,N-diethyldithiocarbamate, sulfamide, sulfamic acid, phenylbo …
LjCAA1 showed a high catalytic activity for the CO2 hydration reaction, with a k(cat) of 7.4∗10(5) s(-1) and a k(cat)/K …
7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.
Tanc M, Carta F, Bozdag M, Scozzafava A, Supuran CT. Tanc M, et al. Among authors: scozzafava a. Bioorg Med Chem. 2013 Aug 1;21(15):4502-10. doi: 10.1016/j.bmc.2013.05.032. Epub 2013 May 31. Bioorg Med Chem. 2013. PMID: 23769167
A series of 7-substituted sulfocoumarins and 3,4-dihydrosulfocoumarins was obtained by cyclization of the methanesulfonate of 2,4-dihydroxy- or 2-hydroxy-4-methoxybenzaldehyde, followed by derivatization reactions. The new compounds incorporate a range of substituen
A series of 7-substituted sulfocoumarins and 3,4-dihydrosulfocoumarins was obtained by cyclization of the methanesulfonate of 2,4-dih
Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors.
Trabocchi A, Pala N, Krimmelbein I, Menchi G, Guarna A, Sechi M, Dreker T, Scozzafava A, Supuran CT, Carta F. Trabocchi A, et al. Among authors: scozzafava a. J Enzyme Inhib Med Chem. 2015 Jun;30(3):466-71. doi: 10.3109/14756366.2014.947976. Epub 2014 Sep 8. J Enzyme Inhib Med Chem. 2015. PMID: 25198885
The protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme, which catalyses the irreversible conversion of peptidyl-arginines into peptidyl-citrullines and plays an important role in several diseases such as in the rheumatoid arthritis, multiple sclerosis, Alzhe …
The protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme, which catalyses the irreversible conversion of peptidyl-argini …
Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.
Güzel O, Maresca A, Scozzafava A, Salman A, Balaban AT, Supuran CT. Güzel O, et al. Among authors: scozzafava a. J Med Chem. 2009 Jul 9;52(13):4063-7. doi: 10.1021/jm9004016. J Med Chem. 2009. PMID: 19438226
A series of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides has been derivatized by reaction with 2,4,6-trimethylpyrylium perchlorate, leading to pyridinium derivatives. ...
A series of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides has been derivatized by reaction with 2,4,6-trimethylpyrylium perch
568 results
Jump to page
Feedback